What are the main manifestations of the harm of bile duct cancer?

The pain that diseases bring to patients is indescribable, especially some particularly dangerous diseases, which make patients suffer physically and mentally, and they are in agony. Cholangiocarcinoma is such a dangerous disease, which endangers the physical and mental health of patients. So what are the main manifestations of the harm of cholangiocarcinoma? Let's learn about it together.

Without any surgery or drainage, most patients with bile duct cancer die within 3 months after diagnosis. The 1-year and 3-year survival rates of more thorough tumor resection are 90% and 40%, respectively, while those with palliative surgery are only 55% and 10%. The survival time of advanced patients with simple drainage rarely exceeds 1 year. Literature reports that the survival time of upper, middle and lower bile duct cancer is (8.75±6.31), (10.31±8.01) and (14.48±12.95) months, respectively. Therefore, the harm of bile duct cancer is extremely great. It is mainly manifested in the following points:

1. Biliary obstruction Cholangiocarcinoma will first cause bile duct obstruction in patients, which will lead to functional disorders of the bile duct system, and then cause digestive system disorders in patients, leading to anorexia in patients.

2. Liver failure. Cholangiocarcinoma can easily lead to liver failure in patients, which is a very important reason for the death of many bile duct cancer patients.

3. Biliary fistula Biliary duct cancer often causes bile fistula in patients. This is the most common and serious complication after bile duct cancer surgery. Because there are many openings in the intrahepatic bile duct, it is sometimes difficult to properly handle, making it easy for patients to have bile fistula after surgery.

4. The most common symptom of late-stage cholangiocarcinoma is metastasis, which is a dynamic and continuous process. First, tumor cells invade and break through tissue barriers to enter blood vessels and lymphatic vessels to form cell emboli, which then fall off and run in the blood or lymphatic vessels. Then, they adhere to and stay in the microcirculatory endothelial cells of distant organs, pass through the microcirculation, reproduce in the new tissue and organ substance, and grow into new metastatic tumors.

In addition, during the metastasis of cholangiocarcinoma, cancer cells can also fall directly into the body cavity and implant on the serosal surface to form implanted metastatic tumors.

5. Massive intraperitoneal hemorrhage Massive intraperitoneal hemorrhage is also a common and serious hazard of bile duct cancer and a common complication after bile duct cancer surgery. This situation often occurs in patients with combined liver lobectomy and portal vein damage during surgery.