How much do you know about osteosarcoma

When it comes to osteosarcoma, everyone is familiar with it. It is very harmful to people. Many people suffer from it, and serious cases can endanger their lives. However, many people lack knowledge about osteosarcoma and know very little about it, which delays the best treatment time and causes more serious consequences. So now let's learn about the issue of osteosarcoma together!

1. Overview of osteosarcoma:

Osteosarcoma, also known as osteogenic sarcoma, is a common malignant bone tumor occurring in adolescents or children under the age of 20. It is the most common malignant bone tumor in children, accounting for about 5% of all pediatric tumors.

2. Causes of osteosarcoma:

Osteosarcoma is the most common type of malignant bone tumor. It develops from the mesenchymal cell line. The rapid growth of the tumor is due to the direct or indirect formation of tumor bone-like tissue and bone tissue through the cartilage stage. Under the influence of external factors (such as viruses), the weight-bearing bones of the lower limbs cause cell mutations, which may be related to the formation of osteosarcoma.

Typical osteosarcomas originate from the bone, while another completely different type of osteosarcoma is the osteosarcoma that is parallel to the bone cortex and originates from the periosteum and nearby connective tissue. The latter is less common and has a slightly better prognosis.

3. Clinical manifestations of osteosarcoma:

The prominent symptom of osteosarcoma is pain at the tumor site, which is caused by the tumor tissue eroding and dissolving the bone cortex.

1. Pain

Pain of varying degrees at the tumor site is a very common and obvious symptom of osteosarcoma. It is caused by the expansion of the tumor tissue destroying the bone cortex and stimulating the periosteal nerve endings. The pain may develop from intermittent in the early stage to continuous after a few weeks, and the degree of pain may increase. Pain in the lower limbs may cause pain-avoiding claudication

2. Lump

As the disease progresses, local swelling may occur, and a lump may be felt at the painful part of the limb, accompanied by obvious tenderness. If the lump grows rapidly, the lump can be found from the appearance. The skin temperature on the surface of the lump increases and the superficial veins are exposed. The surface of the lump and the nearby soft tissue may have varying degrees of tenderness. Due to different degrees of ossification, the hardness of the lump varies. As the lump grows, it causes limited joint movement and muscle atrophy.

3. Limping

Analgesic claudication caused by limb pain worsens as the disease progresses. Patients with long-term illness may experience limited joint movement and muscle atrophy.

4. General condition

When the diagnosis is confirmed, the general condition is generally poor, manifested by fever, malaise, weight loss, anemia and even exhaustion. In some cases, the tumor grows very quickly and metastasizes to the lungs at an early stage, causing the general condition to deteriorate. Pathological fractures at the tumor site make the symptoms more obvious.