What factors are related to the occurrence of bile duct cancer

The occurrence of bile duct cancer makes many people feel at a loss, not only because of the fear for life, but also because of the torture of illness. However, the occurrence of any disease is not without cause. So, what factors are related to the occurrence of bile duct cancer? What are its pathogenic factors? Please follow the editor to find out.

Cholangiocarcinoma is the most common tumor among malignant tumors of the gallbladder. Its clinical manifestations are diverse and its cause is still unknown. Factors that may be related to its onset include ulcerative colitis, gallstones, Clonorchis sinensis infection, common bile duct cysts, etc. These factors can increase the risk of cholangiocarcinoma.

Data show that about 1/3 of patients with bile duct cancer have concurrent bile duct stones, and 5% to 10% of patients with bile duct stones will develop bile duct cancer. It is generally believed that the long-term mechanical stimulation of the bile duct wall by hepatobiliary stones and the resulting chronic biliary infection and bile stasis lead to chronic proliferative inflammation of the bile duct wall, which in turn causes atypical hyperplasia of the bile duct mucosal epithelium. Pathological observations have found that atypical hyperplasia of the bile duct mucosal epithelium can gradually transition into adenocarcinoma.

In addition to gallstones, the most concerning thing is the infection with Clonorchis sinensis. In Southeast Asia, people infected with liver flukes due to eating raw fish suffer from bile duct infection, bile stasis, peribiliary fibrosis and bile duct hyperplasia, resulting in a high incidence of bile duct cancer. In areas where people are used to eating foods rich in nitrite, the possibility of inducing cancer is even greater.

By reading the editor's introduction, we learned about the causes of bile duct cancer. Only by understanding these causes can we help people prevent and treat bile duct cancer, strive to keep people away from bile duct diseases and stay healthy, avoid the occurrence of such diseases and avoid too many health hazards.