The main causes of osteosarcoma in adults

Osteosarcoma is difficult to cure and is prone to recurrence, and this disease is mostly seen in adults. So, everyone must be very concerned about the main cause of osteosarcoma in adults. Here I will first introduce to you what is osteosarcoma? Osteosarcoma, also known as osteogenic sarcoma, is a malignant bone tumor that develops from the mesenchymal cell line. After understanding osteosarcoma, let's take a look at the main causes of osteosarcoma in adults?

The occurrence of osteosarcoma is related to the following factors.

1. What are the causes of osteosarcoma? Heredity: The retinoblastoma gene Rb gene is located on chromosome 13q14. It is currently known that it is a tumor suppressor gene mutation or deletion. Patients with hereditary retinoblastoma have a much higher risk of osteosarcoma than the average person. In recent years, it has been found that some osteosarcoma patients also have mutations in the Rb gene.

2. Viruses: Experiments have shown that animal osteosarcoma is related to viral infection, but there is no definite data to explain the relationship between human osteosarcoma and viruses.

3. Malignant transformation of benign bone diseases: such as multiple osteochondromas, Paget's disease of bone, fibrous dysplasia of bone, etc., which may lead to osteosarcoma, also known as secondary osteosarcoma.

4. Active growth of bones.

5. Radiation: Experiments have shown that any radioactive substance that can accumulate in the bones can induce osteosarcoma; local radiation therapy for certain bone diseases such as giant cell tumor of bone, aneurysmal bone cyst or extra-bone tumors such as breast tumor, retinoblastoma, etc. can occasionally cause secondary osteosarcoma.

The above are the causes of osteosarcoma in adults that we want to share with you. We hope it will be helpful to you.