Are the genetic factors of uterine cancer clear?

Irregular vaginal bleeding before and after menopause is the main symptom of endometrial cancer. It is usually a small to moderate amount of bleeding, and rarely a large amount of bleeding. Not only are younger or near-menopausal patients prone to mistaking it for irregular menstruation and not seeking medical treatment in time, but even doctors often neglect it. Some people also have delayed menstrual cycles, but the symptoms are irregular. Are the genetic factors of uterine cancer clear?

Cancer is not a directly inherited disease, but a few cancers do tend to run in families. If someone in the family has cancer, the chances of their children getting cancer are several times higher than that of the average person. Which women are most likely to develop endometrial cancer:

1. Infertility

The high risk factor of endometrial cancer decreases with the increase of the number of births. Women with infertility caused by long-term anovulation are more likely to suffer from this disease than women who have given birth to one child. Patients with polycystic ovary syndrome are also prone to this disease for the same reason.

2. People who take exogenous estrogen for a long time for various reasons

The use of exogenous estrogen alone without progestin antagonism may increase the risk of endometrial cancer, which is related to the dose and duration of estrogen use. If progestin is added to antagonize, the risk can be reduced.

3. People with menstrual disorders, early menarche or delayed menopause

In the period before menopause, the woman is often in an anovulatory state, and the endometrium undergoes proliferative changes after being stimulated for a long time by a single estrogen without progesterone opposition.

4. Diabetes and hypertension

Some patients with diabetes, hypertension, etc. may develop polycystic ovary syndrome, atypical endometrial hyperplasia, and excessive estrogen levels in the body due to long-term pituitary abnormalities, which is also a cause of cancer.