Is lung cancer gene mutation hereditary?

Is lung cancer gene mutation hereditary? Scientists point out that congenital genetic genes and acquired eating habits, living environment, occupation, etc. are all related to the incidence of cancer, and acquired factors play a major role. Even people with a genetic tendency to lung cancer need the continuous influence of the external environment to form a tumor.

Therefore, as long as we adopt a reasonable lifestyle and appropriate eating habits, we can effectively prevent the occurrence of cancer. The same is true for lung cancer. As long as we pay attention to not actively or passively smoking, avoid the influence of polluted ambient air, and avoid the influence of occupational carcinogens (such as asbestos, chromium, nickel, and arsenic), even if lung cancer is confirmed to be hereditary, it can greatly reduce the incidence of lung cancer.

Cancer is not an infectious disease. Its hereditary nature refers to genetic susceptibility, that is, the offspring of parents with cancer are more likely to get cancer than others. Of course, the probability is very low; but it is not certain. Cancer is a low-probability disease, and many cancers, such as lung cancer, are closely related to lifestyle. Therefore, it is recommended not to worry about the inheritance of lung cancer and to establish a good lifestyle.

The transformation of normal cells into tumor cells is based on the genetic disorder of genomic changes, but whether this change can eventually evolve into clinical cancer is also determined by various environmental carcinogens and other internal factors, including anti-cancer genes, growth factors, growth factor receptors, chromosome stability, etc. More and more evidence shows that genetic characteristics.

It can change the risk of an individual developing lung cancer, because the metabolites of carcinogens can cause malignant changes, and the pathways for producing metabolites are determined by genetics, including lung cancer caused by smoking and occupational damage. Family surveys and studies have shown that non-smokers with a family history (lung cancer patients in the family) have a higher risk of developing lung cancer than those without a family history. The potential mechanism of this familial aggregation has been under study, and it is now speculated that genetic factors determine the ability to metabolize carcinogens, which may play an important role in changing the risk of lung cancer.

Studies have shown that the induction of aromatase in lung cancer patients is greatly enhanced. The concentration of this enzyme is controlled by genes, and it can activate polycyclic aromatic hydrocarbons and aromatic compounds contained in tobacco into potential carcinogens. Although the molecular and genetic events of lung cancer pathogenesis are active areas of research, there is no definite genetic change to explain the risk of lung cancer. Therefore, there is no definite statement on the inheritance of lung cancer.