What are the main causes of colorectal cancer?

What are the main causes of colorectal cancer? I believe many people have this question. There are still many factors in life that can induce colorectal cancer. Let us follow the experts to learn about the causes of colorectal cancer .

1. Dietary factors: Epidemiological studies have shown that diet is an extremely important factor in the development of tumors, because 70% to 90% of tumors are related to environmental factors and lifestyle, and 40% to 60% of environmental factors are related to diet and nutrition to a certain extent. This is one of the causes of colorectal cancer.

2. Low-fiber diet: Dietary fiber refers to plant polysaccharides and lignin in plant foods that cannot be hydrolyzed by human digestive enzymes. Higginson once noticed that the rarity of colon cancer in Africa is related to the large amount of coarse grains consumed and little constipation.

3. Nitrosamine compounds: Many nitrosamine compounds are strong carcinogens, and they can induce tumors in almost all organs in animal experiments. Generally, small doses of nitrosamines can cause cancer if they are exposed for a long time. Nitrosamine compounds are widely found in food additives and pickled foods such as meat, fish, and vegetables treated with nitrites (such as bacon, ham, salted fish, etc.). Animal experiments have confirmed that hydrazine substances converted into nitrosamine compounds by intestinal bacteria can cause colorectal cancer. Domestic research by Yang Gong and others found that the positive correlation effect of pickled foods is an independent risk factor for colorectal cancer. Those who consume pickled foods more than 3 times a week have an excess risk of colon cancer that is 2.2 times (P<0.01) that of those who consume pickled foods less than once, 2.3 times (P<0.01) for rectal cancer, 2.1 times for left-side colon cancer, and 1.8 times for right-side colon cancer. This is also the cause of colorectal cancer.

4. Vitamins: Case-control studies have shown that carotene, vitamin B2, vitamin C, and vitamin E are all associated with a lower relative risk of colorectal cancer, and statistical tests have reached a significant level, and there is a dose-response relationship. For example, Chiu et al. reported in 2003 that high intake of vitamin C, carotene, and vitamin E is associated with a lower risk of colon cancer. McCullough et al. reported in 2003 the results of follow-up observations of 60,866 male and 66,883 female participants, suggesting that vitamin D can reduce the risk of colorectal cancer in men (RR=0.71, 95%CI=0.51, 0.98), and calcium has a protective effect in the occurrence of colorectal cancer (RR=0.87, 95%CI=0.67, 1.12).

The above is an introduction to the causes of colorectal cancer. I hope the above content can be helpful to you. If you have any questions about colorectal cancer, you can contact our online experts and they will give you detailed answers.

For more information, please visit the colorectal cancer special page at http://www..com.cn/zhongliu/ca/ or seek free consultation from an expert, who will provide a detailed answer based on the patient's specific situation.