A brief discussion on the key points of diagnosis of lymphoma

Lymphoma is not uncommon in my country. People with lymphoma can be found in all age groups. As age increases, the incidence rate also increases. So, what are the key points for diagnosing lymphoma? Below we will introduce it in detail, hoping to help patients detect the disease early.

1. Tumor markers, lymph node biopsy, lymphoma should generally be confirmed by pathological examination, and its pathological examination specimens should undoubtedly be mainly lymph nodes. Bone marrow biopsy, the incidence of bone marrow invasion of lymphocytic lymphoma can be as high as 40-90%, while the incidence of diffuse histiocytic lymphoma is only 5-15%. Due to the clinical importance of bone marrow examination and the focality of metastasis, more than one puncture biopsy is often required. Liver biopsy, small lymphocytes and small cleaved cells in non-Hodgkin's lymphoma are more likely to invade the liver than large cleaved cells. Blood picture, most white blood cells in Hodgkin's disease are normal, a few are slightly or significantly increased, accompanied by neutrophilia, about 1/5 of the cases have eosinophilia, and late lymphocytopenia. Bone marrow picture is not very meaningful for diagnosis. If a bone marrow biopsy is performed, the positive rate of lymphoma can be increased by 9-22%. In the bone marrow picture of Hodgkin's disease, if R-S cells can be found, it will be helpful for diagnosis. Hematology is one of the key points in the diagnosis of lymphoma. Erythrocyte sedimentation rate increases and serum lactate dehydrogenase activity increases during the active stage of the disease. When serum alkaline phosphatase and blood calcium increase, it indicates bone marrow involvement. Due to the increase in binding globulin and plasma ceruloplasmin, the main binding protein can also be used as an indicator of lymphoma activity. Immunology and genetics, in the early stage of Hodgkin's disease, about 10% of patients have mild hyperplasia of IgG and IgA, while IgM decreases. In the late stage, 2.9% of patients show hypogammaglobulinemia.

2. Imaging examinations include X-ray examination, computed tomography (CT), magnetic resonance imaging (MRI), radioisotope scanning, and ultrasonic examination.

After reading the above introduction, I believe you have understood the key points of lymphoma diagnosis. If you have other questions, you can come to our hospital for detailed consultation.

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