What are the factors that cause nasopharyngeal carcinoma

Nasopharyngeal cancer is more common in men, and most cases occur in middle-aged people, but there are also teenagers who suffer from it. The cause of nasopharyngeal cancer is related to racial susceptibility (yellow people are more likely to suffer from it than white people), genetic factors, and Epstein-Barr virus infection. So what are the pathogenic factors of nasopharyngeal cancer?

1. Genetic factors

There is a racial and familial clustering of nasopharyngeal carcinoma patients, and nasopharyngeal carcinoma may be a hereditary disease. Recently, the correlation between certain genetic factors that determine HLA and nasopharyngeal carcinoma has been discovered. There are reports that the chromosome aberration of peripheral blood lymphocytes in families with a high incidence of nasopharyngeal carcinoma is related to the genetic susceptibility to nasopharyngeal carcinoma.

2. EBV infection

EB virus-infected cells can produce a variety of EB virus-specific antigens, including early antigen (EA), capsid antigen (VCA), membrane antigen (MA) and nuclear antigen (NA). After being infected with EB virus, the human body will produce various corresponding antibodies. The positive rates of EB virus EA-IgA and VCA-IgA antibodies in nasopharyngeal carcinoma patients were 96% and 81.5%, respectively, indicating that these two antibodies can be used as serological diagnostic markers for nasopharyngeal carcinoma, but the positive rate of EA-IgA antibodies in normal people is higher, and it is not as specific as VCA-IgA in diagnosing nasopharyngeal carcinoma. Further studies have shown that the detection of EA-IgA antibodies in serum is more specific than VCA-IgA antibodies, but not as sensitive as VCA-IgA. People who are positive for VCA-IgA antibodies are at high risk of developing nasopharyngeal carcinoma.

3. Environment and Diet

Environmental factors are also a cause of nasopharyngeal cancer. It is reported that the second generation born in the United States has a lower risk of nasopharyngeal cancer than the first generation born in Asia, while white people born in California in Southeast Asia have a higher risk of nasopharyngeal cancer than those born in the United States. In Guangdong, a survey found that the content of trace element nickel in rice and water in areas with a high incidence of nasopharyngeal cancer is higher than that in areas with a low incidence. The nickel content is also high in the hair of nasopharyngeal cancer patients. Nickel may be a cancer-promoting factor. Dinitrosopyrazine (DNP) is related to the occurrence of nasopharyngeal cancer. Eating salted fish and pickled foods is a high-risk factor for nasopharyngeal cancer in southern China, and is related to the age, duration, frequency and cooking methods of eating salted fish. This is related to the high concentration of nitrosamine compounds in salted fish and pickled products.

The above is an introduction to the pathogenic factors of nasopharyngeal carcinoma. I hope it will be helpful to everyone. Expert Tips: If you have symptoms of disease, do not delay diagnosis and go to a regular hospital for treatment in time to avoid delaying the disease and causing serious consequences. If you have other questions, please consult our online experts or call for consultation. Believe in miracles and wish you health, happiness and joy!

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