Attention! How is liver cancer caused

Liver cancer is divided into primary and secondary. Primary liver cancer refers to cancer that occurs in liver cells or intrahepatic bile duct cells. It is one of the most common malignant tumors, and its mortality rate ranks third among digestive system malignancies, second only to gastric cancer and esophageal cancer. Next, let's learn about the causes of liver cancer.

Among liver cancers in my country, hepatocellular carcinoma (HCC) accounts for about 80%-90%, followed by cholangiocarcinoma and mixed hepatocellular and cholangiocarcinoma. Clinical symptoms include liver pain, upper abdominal mass, progressive weight loss, etc. Malignant tumors originating from other cell components of the liver are rare. Liver cancer has the characteristics of insidious onset, long incubation period, high malignancy, rapid progression, strong invasiveness, easy metastasis, and poor prognosis. Its incidence rate has been increasing year by year.

According to the analysis of a large amount of research data at home and abroad, the main causes of liver cancer are as follows:

(1) Viral hepatitis : mainly hepatitis B and C virus infections, especially hepatitis B and hepatitis B virus carriers, whose incidence of primary liver cancer is 2 to 100 times higher than that of normal people; in areas with a high incidence of liver cancer, about 20% of people may be hepatitis B or hepatitis B virus carriers.

(2) Aflatoxins (AFT): Aflatoxin B is the most important carcinogen. It thrives in high temperature and high humidity environments, especially in summer when moldy foods, grains, and feed are most likely to be contaminated by Aspergillus flavus and produce aflatoxins. Long-term consumption of foods containing this toxin can induce liver cancer.

(3) Water pollution : Severe pollution of drinking water is one of the important causes of liver cancer, especially polluted ditch water, followed by river water, and well water. Therefore, in villages without tap water facilities, drinking well water should be encouraged.

(4) Chemical carcinogens: Chemical substances that can cause liver cancer are mainly N-nitroso compounds, such as nitrosamines and nitrosamides. In addition, pesticides, alcohol, safrole, etc. can also induce liver cancer.

( 5) Other factors : Overnutrition (macronutrients) or nutritional deficiency (such as vitamin A, B1 deficiency), hemochromatosis, parasitic infection and heredity are also risk factors for liver cancer.

(6) Immune status : Some people believe that the plasma of liver cancer patients contains a blocking factor that can inhibit cellular immunity and protect liver cancer cells from being killed by immune cells. It has been proven that alpha-fetoprotein (AFP) can inhibit the phagocytosis of lymphocytes and macrophages.

( 7) Gene mutation : In recent years, some people believe that mutagens and viruses in the environment stimulate the activation of liver cell division response pathways, causing point mutations and gene translocations in cells, which is a possible factor in accelerating the proliferation of cancer cells.

In addition, the occurrence of liver cancer is also related to the abnormal regulation of cell cycle by non-blood protein nuclear proteins, as well as intracellular and extracellular factors such as cyclic nucleotides, hormones, peptides, growth factors and polyamines.

The above is an introduction to how liver cancer is caused. I believe that everyone has a certain understanding of it. Experts remind: If you find abnormal symptoms in your body, it is recommended to go to a regular hospital for examination to stay away from viruses. If you have any questions, please consult online experts, who will give you detailed answers. Feihua Health Network has always been by your side and cared about your health issues! Feihua Health Network wishes you good health!

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