How to remove scleroderma

How to remove scleroderma?

People all want to have a healthy body. As the saying goes, "the body is the capital of revolution." Human health is very important. However, some people have various body problems due to fatigue or stress, such as physical weakness and physical deficiency. Others have muscle and bone pain, which seriously affects their lives. This is a common manifestation of scleroderma. How to get rid of scleroderma? Let’s take a look at it next.

2. Common symptoms of scleroderma

The main features are fibrosis or sclerosis of the skin, synovium, skeletal muscle, blood vessels and esophagus. Some internal organs, such as the lungs, heart, and kidneys

1. Typical symptoms of scleroderma

The main manifestations are Raynaud's phenomenon, fatigue, musculoskeletal pain, etc.

2. Common symptoms of scleroderma

The main features are fibrosis or sclerosis of the skin, synovium, skeletal muscle, blood vessels and esophagus. Some internal organs, such as the lungs, heart, kidneys, and large and small arteries may also have similar lesions. The severity of the disease varies. In mild cases, only the fingers and facial skin are affected (localized type). Early symptoms include swelling of the face, hands and (or) feet, tight skin that cannot be lifted, and a sausage-like shape, also known as sausage-like fingers. The skin gradually thickens, and the skin lines and wrinkles disappear. In the late stage, the skin becomes hard and atrophy, the facial skin becomes thin, the expression is dull, the nose becomes pointed, the earlobes become thin, and the mouth opening is restricted, like a mask. In most patients, Raynaud's phenomenon is the first symptom of the disease, and some patients experience skin changes more than 10 years after Raynaud's phenomenon. One-third of patients may experience joint pain and stiffness, and a few have definite arthritis. In addition, some patients present with severe muscle weakness, which is difficult to distinguish from myositis.

3. Other symptoms of scleroderma

For some patients, the disease progresses gradually, and it often takes a long time, even decades, before clinical manifestations of specific visceral involvement appear. People with severe scleroderma may have widespread skin changes involving the chest, abdomen, and back (diffuse form). Patients with diffuse scleroderma may have internal organ involvement. Some patients are found to have important organs such as the kidneys and heart affected when they become ill. The disease progresses dangerously and may even be life-threatening.

IV. Treatment principles

Symptomatic treatment is adopted, including vasodilation, anti-fibrosis and immunomodulation.

5. Treatment Guidelines

Quitting smoking, avoiding cold, keeping the whole body warm and performing biofeedback exercises are effective in preventing Raynaud's phenomenon; vasodilators should be used when symptoms are severe or accompanied by fingertip ulcers.

6. Drug treatment

1. Drugs targeting blood vessels and improving microcirculation include aspirin and dipyridamole, which change platelet function. Ketanzerin is a histamine antagonist that can reduce the frequency and severity of Raynaud's phenomenon and improve the prognosis of digital ulcers. However, the drug is ineffective in improving skin thickening or internal organ damage. The calcium channel blocker nitrendipine is a potent vasodilator. Angiotensin-converting enzyme inhibitors such as meprobamate and enalapril can effectively control hypertension and early renal insufficiency. Other drugs that improve microcirculation include Danshen and low-molecular-weight dextran injection, which have certain effects on skin sclerosis, joint stiffness and pain.

2. After one month of use, the dosage of glucocorticoids and immunosuppressant prednisone should be reduced to maintain the condition. Methotrexate and cyclosporine A (CsA) have shown some efficacy in trials with a small number of people. Penicillamine is an immunomodulator that has a certain effect on inhibiting skin sclerosis and visceral damage. For patients with interstitial lung disease, glucocorticoids and CTX can change the condition, while tripterygium wilfordii glycosides and macrolides such as roxithromycin can alleviate symptoms. Intravenous prostaglandins increase survival in patients with primary pulmonary hypertension.

7. Other treatments

Improvements in hemodialysis and renal dialysis therapy have also brought hope for renal crisis, and kidney transplantation has improved survival rates.