Cell proliferation is caused by inflammation

Cell proliferation is a very common disease. Cell proliferation can cause an imbalance in cell development in the human body, thereby leading to an imbalance in human functions. Generally speaking, many factors can lead to cell proliferation in the human body. If you suffer from cell hyperplasia, you should first go to the hospital for examination to determine the specific cause and then receive treatment. So, is cell proliferation caused by inflammation?

The disease is mainly composed of proliferating Langerhans cells, eosinophils and other inflammatory cells. Multinucleated giant cells and necrotic tissue can also be seen. There is often a layer of uninvaded connective tissue band under the epithelium (fig.3).

Langerhans cells are mostly focal or sheet-like aggregates with large cell size, abundant cytoplasm, weak eosinophilia, round, oval or lobed nuclei, prominent nucleoli, and often nuclear grooves (fig.4,5).

In Han Xueke disease, a large number of tissue cells that phagocytize lipids, called foam cells, can be seen around the necrotic area, while eosinophils are relatively rare.

In Lecher's disease, Langerhans cells proliferate massively, with many anomalous nuclei and nuclear division phases, but no foam cells.

OKT6 and S-100 protein (fig.6) can be used as immunohistochemical markers for Langerhans cells. Both the cytoplasm and the nucleus were strongly positive. Under the electron microscope, the cytoplasm electron density of Langerhans cells is low, and they are also called bright cells. The nuclear membrane of the cell nucleus is invaginated to form a defect. Characteristic Langerhans granules, also known as Birbeck granules, can be seen in the cytoplasm. They are rod-shaped, with a bounded membrane, and the granules are 0.2-1um long and 40nm wide. The surface has regularly spaced horizontal stripes, or one end is swollen and shaped like a tennis racket (fig.7).

It consists of three parts: (1) cell growth, the duplication of all structural components and functional potential, which is morphologically manifested as an increase in cell size; (2) DNA replication, the essential genetic prerequisite for completing cell division, allowing the daughter chromosomes to be accurately distributed to form daughter nuclei; (3) mitosis, the division of the cell into two daughter cells. The speed varies among different organizations. The production of new cells is always balanced by the loss of cells. Factors such as radiation, carcinogens, and viruses can cause cells to lose their regulatory functions.