Is neutrophil inflammation asthma?

We all know that asthma is very harmful. First of all, asthma can cause breathing difficulties, and the feeling of being unable to go up or down can make people feel very depressed, as if something is blocking the chest cavity, which always makes us feel very irritable. Because everyone is afraid of asthma, when they are diagnosed with the disease by the center, they don’t know what to do.

describe

Description of neutrophils: The most numerous, irregular in shape, often with peripheral protrusions, and light red cytoplasm. The immature nucleus is rod-shaped or horseshoe-shaped, while the mature one is lobed, with triplobe being more common.

source

Neutrophils originate from hematopoietic stem cells in the bone marrow. After differentiation and development in the bone marrow, they enter the blood or tissues. The distribution ratio in bone marrow, blood and connective tissue is 28:1:25. The number of neutrophils in adult blood accounts for about 55% to 70% of the total white blood cells. Neutrophils are a type of polymorphonuclear leukocytes. Since their number is the largest among granulocytes, some people refer to polymorphonuclear leukocytes as neutrophils.

structure

The cells contain many diffusely distributed tiny light red or light purple unique granules, which contain myeloperoxidase, acid phosphatase, phagocytosis, lysozyme, etc. Myeloperoxidase is unique to neutrophils and is present in very low or no amounts even in macrophages, which have a strong phagocytic ability. In cytochemistry, myeloperoxidase is generally used as a marker for neutrophils. Neutrophils have a strong chemotactic effect. Chemotaxis is the movement of cells toward the direction stimulated by a chemical substance. Substances that have a chemotactic effect on neutrophils are called neutrophil chemotactic factors. There are chemokine receptors on the neutrophil membrane. The receptors bind to the chemokines, activating the calcium pump on the cell membrane. The cell extends its lamellae forward, causing the cell to move toward the site where the chemokine is produced.

When the lamellipodia of neutrophils come into contact with foreign bodies that produce chemotactic factors, the cytoplasm around the contact point forms protrusions called pseudopodia, and the cell membrane at the contact site is concave, surrounding the foreign body to form a phagosome or phagocytic vacuoles containing the foreign body. There are IgGFc receptors and complement C3 receptors on the surface of neutrophil membranes, which can accelerate phagocytosis. When the phagocytosed foreign matter is coated with antibodies and complement, it binds to the corresponding receptors on the neutrophil membrane, thereby enhancing the cell's phagocytic effect on it, which is called opsonization.