Inheritance of sweat gland cancer

There are sweat glands in the human body. The reason why we sweat is because of the secretions of the sweat glands. The more abundant the sweat glands are, the more secretions they produce. However, poor maintenance or many problems can also lead to sweat gland cancer. After sweat gland cancer occurs, it is very important for patients to find a way to treat it, and they also need to understand genetic factors.

Pathogenesis

Depending on the location of the tumor cells in the sweat glands, there are apocrine carcinoma and eccrine carcinoma.

1. Carcinoma of large sweat gland: It occurs in the apocrine glands and is often a solid, invasive and metastatic malignant tumor. According to the histopathological characteristics, it is divided into 5 types:

(1) Undifferentiated type: There are two types of cancer cells, one with clear or lightly eosin-stained cytoplasm and small polygonal or oval shapes; the other with dark eosin-stained cytoplasm and spindle shapes. The cancer cells were obviously atypia-like, arranged in cords or plaques, with a tendency to form glands, and no PAS-positive material was found (Figure 1).

(2) Differentiated type: There are also two types, which are similar to the undifferentiated type, but the cells with lightly stained cytoplasm are larger and appear as large polygons or cubes. Cancer cells are intertwined and arranged in nodules, tending to form glandular cavities or cysts. Some cancer cells contain PAS-positive substances.

(3) Glandular type: composed of cubic or columnar epithelial cells, forming glandular cavity. PAS-positive substances were found in glandular epithelial cells and glandular cavities.

(4) Mucoepidermoid type: It is composed of atypical squamous cell nests and columnar cells containing clear mucus or rich in granules.

(5) Eczematous cancer type: cancer cells invade the local epidermis.

2. Carcinoma of eccrine gland occurs in the eccrine glands and is often a substantial, invasive malignant tumor. It is divided into four types according to its histopathological characteristics:

(1) Syringoid eccrine carcinoma: The tumor cells involve the entire dermis and even the subcutaneous tissue, with enlarged ductal cavities opening on the skin surface, which are connected to the epidermis with acanthosis or verrucous hyperplasia. There are interconnected ductal adenoid cystic structures and keratinous cysts can be seen inside. The tumor cells vary in size and have darkly stained nuclei. The split image is easy to see. The interstitium is rich in blood vessels or fibrotic or even cartilage-like. Electron microscopy shows that the epithelium lining the glandular cyst cavity may contain keratinized or ductal cells, as well as secretory cells.