The role and efficacy of coenzyme a

Coenzyme A is an enzyme and a synthetic substance. Many people don’t know much about coenzyme A, let alone its functions and effects. Coenzyme A has many biochemical functions, including activating the body's immunity, promoting the formation and repair of tissues, providing the body with active substances, transferring acyl groups, etc. Below is some introduction about coenzyme A, you can read it and learn more.

Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its roles in the synthesis and oxidation of fatty acids, and in the oxidation of pyruvate in the tricarboxylic acid cycle. All genomes sequenced to date encode enzymes that utilize CoA as a substrate, and approximately 4% of cellular enzymes use (or thioesters such as acetyl-CoA) as a substrate. In humans, CoA biosynthesis requires cysteine, pantothenate, and adenosine triphosphate (ATP). Mainly involved in the metabolism of fatty acids and pyruvate.

1. Biochemical Function

1. Provide energy for the body Coenzyme A is a cofactor for more than 70 enzyme reaction pathways in the body, including the decomposition of carbohydrates, oxidation of fatty acids, decomposition of amino acids, degradation of pyruvate, stimulation of the tricarboxylic acid cycle, and providing 90% of the energy required for life.

2. Provide the active substance coenzyme A to participate in the synthesis of a large number of essential substances in the body. It synthesizes neuromuscular messengers and neurotransmitters such as acetylcholine and melatonin, which promotes sleep, in the brain. Neuromuscular messengers can exchange information between nerves and muscles, and neurotransmitters can transmit information about emotions, external stimuli, memory, learning, etc. between nerves and the brain.

3. Acyl transfer Coenzyme A is an important acetyl and acyl transfer body.

4. Activate the immune function Coenzyme A supports the body's immune system to detoxify harmful substances, activate white blood cells, promote the synthesis of hemoglobin, and participate in the synthesis of antibodies.

5. Promote the formation and repair of connective tissue Coenzyme A can promote the synthesis of connective tissue components chondroitin sulfate and hyaluronic acid, and play an important role in the formation, protection and repair of cartilage.

6. Other effects Coenzyme A promotes the utilization of coenzyme Q10 and coenzyme I, reducing the toxic side effects caused by antibiotics and other drugs.

2. Pharmacological Action

Coenzyme A is extracted from fresh yeast and is a coenzyme for the acetyl reaction in the body. It can combine with acetate to become acetyl-CoA and enter the oxidation process. It plays an important role in the metabolism of sugar, protein and fat. The tricarboxylic acid cycle, the synthesis of acetylcholine, the storage of liver glycogen, the reduction of cholesterol and the regulation of plasma fat content in the body are all closely related to Coenzyme A. However, some people currently believe that the human body does not lack pantothenic acid, the main component of coenzyme A, and that general patients do not need to supplement coenzyme A. In addition, exogenous coenzyme A is a large molecule and is not easy to pass through the cell membrane and enter the cell, so its efficacy is questionable.