What is glycocholic acid checked for

When it comes to the word glycocholic acid, many people may not know what it is and what its function is. However, pregnant women are particularly sensitive to this word. Glycocholic acid is a necessary examination item for pregnant women in the late pregnancy. Glycocholic acid accumulation does not have too serious impact on pregnant women, but it has a greater impact on the fetus. High glycocholic acid may cause premature birth or even death of the fetus. Therefore, once it is found that the level of glycocholic acid is too high, it must be taken seriously and treated in time.

Glycocholic acid is the main bile acid component in serum during late pregnancy. In normal pregnancy, the serum CG level of pregnant women gradually increases with the gestational age, and the CG value of full-term pregnancy increases by 30%-60% compared with non-pregnant women. The normal serum glycocholic acid content is 1.3±0.8mg/L, ranging from 0.4-2.98mg/L. High glycocholic acid in pregnant women has no effect on the pregnant women themselves, but has a great impact on the fetus, which is likely to cause fetal asphyxia and may also cause fetal asphyxia during delivery. It should be taken seriously.

1. The increase in serum glycocholic acid content is positively correlated with the pathological development of liver cirrhosis and is a good indicator for clinical judgment of the degree and prognosis of liver cirrhosis;

2. The blood CG of patients with acute hepatitis, chronic active hepatitis, primary liver cancer, liver cirrhosis, and chronic metastatic liver disease is significantly higher than that of normal people, and increases progressively;

3. The bile duct and gallbladder excretion dysfunction in patients with cholelithiasis and jaundice causes a significant increase in serum CG;

4. The serum CG level of patients with cirrhosis, obstructive liver disease, and enterohepatic circulation disorder is higher than that of normal people;

5. In obstructive liver disease, CG levels increase 10 to 20 times, and serum bile acid also increases in drug-induced cholestasis;

6. In acute hepatitis, chronic active hepatitis, primary liver cancer, cirrhosis and chronic persistent hepatitis, the levels of serum CG were higher than those in the normal control group, and the positive rate decreased in the above order. Especially in the clinical differentiation of chronic active hepatitis and chronic persistent hepatitis, CG can be used as a valuable indicator. The amplitude and frequency of CG increase in chronic active hepatitis are higher than those in chronic persistent hepatitis. It is of great value in judging the progression and remission of chronic active hepatitis, and predicting efficacy and recurrence.

7. Intrahepatic cholestasis of pregnancy, also known as delayed cholestasis of pregnancy, is one of the high-risk pregnancies. Although this disease does not cause the death of pregnant women, it has serious effects on the fetus, easily leading to premature birth, fetal intrauterine distress and even perinatal death.