Specific medicine for ankylosing spondylitis

Nowadays, most people spend a long time looking at their mobile phones or computers every day. Over time, a series of cervical spine diseases will occur. Ankylosing spondylitis is a common one. The main manifestations of this disease are excessive water accumulation in the neck, cell deformation, and unbearable pain. It must be solved by taking medicine in time. There are many specific medicines for the treatment of ankylosing spondylitis. You can choose according to your condition. Here are some recommended treatment drugs.

Ankylosing spondylitis (AS) is a disease characterized by inflammation of the sacroiliac joints and spinal attachment points. Strong association with HLA-B27. Some microorganisms (such as Klebsiella) have common antigens with the susceptible person's own tissues and can induce abnormal immune responses. It is a chronic inflammatory disease characterized by fibrosis and ossification of the large joints of the limbs, the annulus fibrosus of the intervertebral disc and its surrounding connective tissue, and ankylosis of the joints. Ankylosing spondylitis belongs to the category of rheumatic diseases. The cause is still unclear. It is a chronic disease with the spine as the main site of lesions, involving the sacroiliac joints, causing spinal stiffness and fibrosis, and causing varying degrees of eye, lung, muscle, and bone lesions. It is an autoimmune disease.

It is very likely that the disease is caused by multiple factors such as environmental factors (including infection) on the basis of genetic factors. Genetic factors play an important role in the pathogenesis of AS. It is generally believed that it is directly related to HLA-B27. The incidence of AS in HLA-B27 positive people is 10% to 20%. Immune factors are also one of the causes. Some people have found that 60% of AS patients have increased serum complement, most cases have IgA type rheumatoid factor, and serum C4 and IgA levels are significantly increased. Trauma, endocrine, metabolic disorders and allergic reactions are also suspected to be the pathogenic factors.

1. Initial symptoms

For young people aged 16 to 25, especially young men. Ankylosing spondylitis generally has an insidious onset and may not have any clinical symptoms in the early stages. Some patients may show mild systemic symptoms in the early stages, such as fatigue, weight loss, long-term or intermittent low fever, anorexia, mild anemia, etc. As the disease is relatively mild, most patients cannot detect it early, resulting in delayed disease progression and loss of the best time for treatment.

2. Manifestations of joint disease

AS patients often have joint lesions, and most of them first invade the sacroiliac joints and then progress upward to the cervical spine. In a small number of patients, the cervical spine or several spinal segments are first affected, and the surrounding joints may also be affected. In the early stage, there is inflammatory pain in the joints at the lesion site, accompanied by muscle spasms around the joints and a feeling of stiffness, which is more obvious in the morning. It may also manifest as night pain, which is relieved by activity or taking analgesics. As the disease progresses, joint pain decreases, but the movement of each spinal segment and joint becomes restricted and deformed. In the late stage, the entire spine and lower limbs become rigid, arched, and bent forward.