Does magnesium sulfate require monitoring urine output?

In daily life, magnesium sulfate is a relatively common medicine. The medicinal value of magnesium sulfate is very high and it can effectively treat some physical diseases. Pregnant women can also use magnesium sulfate during the period of fetal preservation. During the use of magnesium sulfate, it is necessary to observe the urine volume. This is because large-scale use of magnesium sulfate can easily lead to symptoms of physical poisoning, and it is necessary to observe the urine volume to judge.

Does magnesium sulfate require monitoring urine output?

Excessive use of magnesium sulfate can cause poisoning, which is manifested by less than 150 ml of urine in 24 hours, accompanied by slower breathing and disappearance of knee reflex. During the infusion process, you should also pay attention to changes in fetal heart rate and the presence of uterine contractions. Some patients do not feel pain during uterine contractions, but just feel a tightening in their stomach, so you should also pay attention.

Dosage

oral

1. For catharsis, take 10-40 ml at a time, on an empty stomach in the morning.

2. To promote bile secretion, take 4-10 ml at a time, 3 times a day, before meals.

external use

Duodenal drainage 33% 50ml (sterile solution), or 50% local swelling reduction, etc.

External application method of magnesium sulfate solution alone: ​​Patients should apply hot compress with magnesium sulfate solution plus warm water bag within 48 hours and cold compress for 48 hours. The method is to soak gauze or cotton wool in 50% magnesium sulfate solution, take it out and apply it to the affected area, and place a warm water bag on the gauze or cotton wool. When applying a cold compress, apply magnesium sulfate solution directly to the affected area. The duration of external application is about 15 minutes each time. The number of applications per day can be flexibly controlled according to the size of the nodule and the severity of the inflammatory reaction. The smaller the nodule, the better the treatment effect. Because magnesium sulfate has the pharmacological effects of hypertonicity, detumescence and analgesia, it is used in clinical practice and has achieved relatively satisfactory results.

Adverse Reactions

If a large amount of solution with too high concentration is taken during catharsis, a large amount of water may be absorbed from the tissues and cause dehydration.

1. Intravenous injection of magnesium sulfate often causes symptoms such as twitching, sweating, and dry mouth. Rapid intravenous injection can cause nausea, vomiting, palpitations, dizziness, and nystagmus in some cases. The symptoms can disappear by slowing down the injection speed.

2. In case of renal insufficiency and large dosage of the drug, blood magnesium accumulation may occur. When the blood magnesium concentration reaches 5mmol/L, muscle excitability may be inhibited, sensory reactions may be sluggish, knee tendon reflex disappears, and breathing begins to be inhibited. When the blood magnesium concentration reaches 6mmol/L, respiratory arrest, arrhythmia and heart block may occur. Further increase in concentration may cause cardiac arrest.

3. Continuous use of magnesium sulfate may cause constipation. Some patients may develop paralytic intestinal obstruction, which will improve after stopping the medication.

4. In a very small number of cases, blood calcium levels may decrease, resulting in the recurrence of hypocalcemia.

5. Magnesium ions can freely pass through the placenta, causing neonatal hypermagnesemia, which manifests as low muscle tone, poor sucking ability, inactivity, soft crying, etc. A few may also experience respiratory depression.

6. A small number of pregnant women develop pulmonary edema.