What is xanthelasma?

Xanthelasma is actually a yellow patch formed on the gastric mucosa. Some people think that xanthelasma is a real tumor, but it is not. Currently, most common xanthelasmas are related to chronic gastritis, so friends with chronic gastritis must do relevant care and try their best to avoid the occurrence of such diseases and increase the burden on the stomach.

Symptoms/gastric xanthelasma

Gastric xanthelasma is a yellow-white tumor-like plaque formed in the gastric mucosa. It is not a true tumor and has no special clinical symptoms. It is more common in middle-aged and elderly people. Gastroscopy shows small gray-yellow spots on the mucosa, which are often accompanied by other gastric lesions, most commonly chronic atrophic gastritis. Gastric xanthelasma, also known as yellow tumor or lipid island, is a benign lesion first reported by Endo in 1910 and first reported in China in 1977. The pathogenesis of this disease is not yet fully understood, and most authors believe that it is related to chronic gastritis and intestinal epithelialization. This disease is more common in patients over 50 years old, more common in men, and often occurs in the gastric antrum area. The sizes of the tumors vary, usually less than 5 mm. The clinical manifestations are non-specific and resemble chronic gastritis. Gastroscopy examination showed nearly round white or yellowish-white raised plaques on the antrum and lesser curvature, with clear boundaries, single or multiple, mostly single, and a diameter of 0.2 to 0.6 cm.

It is generally believed that gastric xanthelasma is caused by focal destruction of the gastric mucosa due to chronic gastritis. The residual fat-containing debris is phagocytosed by macrophages and aggregated to form foam cell nest structures. All cases in this group showed chronic inflammatory changes in the gastric mucosa to varying degrees. In the past, it was believed that this disease was related to increased blood lipids, but studies in recent years have shown that this disease has nothing to do with hyperlipidemia.

Diagnosis/Gastric Xanthelasma

The diagnosis can be confirmed through gastroscopy and pathological sections.

During pathological histological diagnosis, it is necessary to differentiate it from gastric signet ring cell carcinoma: the cell nucleus is larger, deeply stained with atypical nuclei, and there are mucus granules in the cytoplasm, which can be identified by strong PAS positivity.

Treatment suggestions/Gastric Xanthelasma Editor Gastric Xanthelasma is generally benign, and there is no special clinical treatment method at present! This kind of plaque on the mucosa will definitely affect the peristalsis and digestive function of the stomach, and of course cause bloating, stomach pain, and acid reflux, but it must be clearly distinguished from gastric ulcer and gastric erosion.

1. Surgical treatment, clean up the macula, remove the tumor (current surgery uses an electronic fiberscope, which is inserted through the mouth, is painless, does not require surgery, and has the advantages of thorough treatment;

2. Take a pathological section of the removed macula;

3. Symptomatic treatment and attention to diet

4. CLS cell immunotherapy can be used for gastric xanthelasma that has become cancerous

CLS cell immunotherapy is a cell immune (T cell, NK cell) therapy developed by CLS, the first high-tech enterprise in the industrialization of tumor immunotherapy in China, in cooperation with American scientific research institutions. It extracts the patient's own immune cells for in vitro culture, using their own cells to treat their own diseases, and there will be no side effects such as bone rejection. More than a thousand tumor patients have received clinical treatment with CLS autologous immune cells. It is currently the most mature, most effective, and most widely used tumor biological treatment technology! CLS cell immunotherapy technology can effectively treat malignant gastric xanthelasma!