What are the causes and hazards of high uric acid?

High uric acid levels are very harmful to your health. For ordinary people, the uric acid in the body can recover on its own, but for patients, uric acid will gradually increase, which will cause disorders in the metabolism of purine substances in the body and cause excessive uric acid in the blood. If you do not pay attention to timely treatment, it can easily lead to fibrosis of joint tissues and even fiber necrosis. Another obvious disease is gout. High uric acid levels often cause joint swelling and pain, skin fever, and dark red skin. Severe cases can also have an adverse effect on kidney function and can easily lead to chronic nephritis. Therefore, when uric acid levels are high, you must pay attention to your diet and try not to eat seafood or foods rich in purine.

Causes of high blood uric acid:

1. Increased purine metabolism: High blood uric acid levels may occur in chronic hemolytic anemia, rhabdomyolysis, polycythemia, myeloproliferative diseases, and during chemotherapy or radiotherapy.

2. Excessive intake of purine: The main reason for high blood uric acid levels is that the high blood uric acid level is directly proportional to the purine content in food. 3. Excessive production of endogenous purine: 1: The de novo synthesis of purine from non-cyclic to cyclic forms requires 11 steps, among which enzyme abnormalities can lead to excessive purine synthesis. 2: Because the main use of purine is as a constituent of DNA and RNA, when cellular RNA and DNA are oxidized and decomposed excessively and synthesis is reduced, a large amount of DNA and RNA fragments will be produced.

High uric acid risk

The first harm of high uric acid: causing joint tissue fibrosis and even necrosis

The harm caused by high uric acid levels mainly lies in the fact that uric acid enters the human body's joint soft tissues through the blood, leading to the precipitation of urate, which causes pathological phenomena in the joints. In clinical practice, patients with more serious high uric acid levels will basically have decreased joint mobility, varying degrees of bone fibrosis, and are also prone to fractures.

The second harm of high uric acid: leading to the occurrence of gout

Gout in the asymptomatic stage is a disease of high blood uric acid. It can be said that as long as there is gout, the blood uric acid level will definitely be high. A gout hospital in Shanghai stated that when gout attacks due to high uric acid, patients will experience obvious adverse symptoms such as joint numbness, severe pain, swelling, hot and dark red skin.

The third harm of high uric acid: the impact on patients and even their functions

The most serious harm of high uric acid is that it causes great damage to the patient's kidney function. Patients with high blood uric acid levels for a long time will gradually see their kidney function decline until it becomes necrotic. The early manifestation is the onset of chronic nephritis.