What are the symptoms of gastrointestinal tumors?

The occurrence of gastrointestinal tumors is definitely not a minor disease, because its impact on the gastrointestinal tract is very large. Patients will experience severe pain and digestion will also be hindered. The appearance of gastrointestinal cancer will bring obvious symptoms, such as intestinal cramps, indigestion, abdominal distension, etc., so it is better to get checked if you encounter such a situation.

The diagnosis can be made based on clinical manifestations, characteristics of skin lesions, and histopathological features. The following points should be noted.

1. Clinically, if tumor nodules appear rapidly in a short period of time (6 to 12 months), are distributed in the skin near the surgical area of ​​the primary tumor or in the corresponding lymphatic drainage area, and their histopathological morphology is similar to that of the primary tumor, especially when they have multiple or multifocal tumor characteristics, they should be considered as skin metastatic cancer.

2. Tumor thrombi are found in the blood vessels or lymphatic vessels of the skin or subcutaneous fat. The distribution configuration of the tumor is a ladder-like form with a wide bottom and a narrow top. It is generally not connected to the epidermis. There is very little inflammatory cell infiltration around the tumor cells, and there is no differentiation of the keratin membrane of the sweat gland ducts. These are often characteristics of metastatic skin tumors.

3. Immunohistochemical markers can help distinguish, for example, tumors originating from sweat glands are GCDFP-15 positive, while tumors of the prostate and thyroid metastases to the skin are PSA and TG positive, respectively. In addition, metastatic skin nodules in the umbilicus and abdomen must exclude endometriosis or implantation nodules, and should also be distinguished from yolk sac or urachal embryonic remnants.