What problems are seen when the activity of neutrophil alkaline phosphatase is significantly increased?

The activity of neutrophil alkaline phosphatase is significantly increased, and you must pay attention to which diseases are causing it. Common viral infections will show a significant increase, and leukemia and aplastic anemia may also show this symptom.

(1) NAP activity is significantly increased in acute suppurative infections, while its activity is within the normal range or slightly lower in viral infections. Therefore, NAP can be used to differentiate between bacterial and viral infections;

(2) The NAP activity of chronic myeloid leukemia is significantly reduced, and the integral value is often 0. The NAP activity of the leukemoid reaction is extremely increased, so it can be used as an important indicator for distinguishing it from chronic myeloid leukemia.

(3) In acute myeloid leukemia, the NAP integral value is reduced; in acute lymphocytic leukemia, the NAP integral value is often increased; in acute monocytic leukemia, the NAP integral value is generally normal or reduced. Therefore, it can be used as one of the methods for identifying acute leukemia.

(4) NAP activity increases in aplastic anemia and decreases in paroxysmal nocturnal hemoglobinuria, which can be used to differentiate between the two.

(5) Other situations: NAP increases when adrenal cortical hormones are used; NAP activity decreases in malignant histiocytosis.