What indicators are included in liver function tests

Liver function tests can detect liver problems, mainly by checking various physical indicators. Many people do not know what indicators are included in liver function tests. Generally speaking, liver function tests need to check indicators of damage to the liver parenchyma, and these need to be carefully adjusted.

1. Indicators reflecting liver parenchymal damage. It mainly includes alanine aminotransferase (ALT, also known as alanine aminotransferase, GPT) and aspartate aminotransferase (AST, also known as aspartate aminotransferase, GOT), among which ALT is the most commonly used sensitive indicator. When 1% of liver cells are necrotic, the serum ALT level can increase by 1 times.

2. Indicators reflecting bilirubin metabolism and cholestasis. It mainly includes total bilirubin (TBil), direct and indirect bilirubin, urinary bilirubin, urobilinogen, blood bile acid (TBA), γ-glutamyl transpeptidase (γGT) and alkaline phosphatase (ALP).

3. Indicators reflecting the synthetic function of the liver. It mainly includes albumin, prealbumin, cholesterol lipase, prothrombin time and activity. When albumin and cholesterol lipase are reduced for a long time and prothrombin activity is decreased and cannot be corrected by vitamin K supplementation, it means that normal liver cells are gradually decreasing, liver cells have poor function in synthesizing proteins and coagulation factors, liver reserve function is reduced, and the prognosis is poor. If the prothrombin time activity is less than 40%, it means that liver failure has occurred.

4. Indicators reflecting liver fibrosis. It mainly includes type III procollagen (PⅢP), type IV collagen (CⅣ), hyaluronic acid (HA), laminin (LN), etc. These indicators can assist in the diagnosis of liver fibrosis and early cirrhosis.

5. Detection indicators of liver coagulation function. The liver can synthesize all coagulation factors except factor III and factor a chain, and plays an important role in maintaining normal coagulation function. The synthesis of coagulation factors in patients with liver disease is reduced, and clinically there may be bleeding from the gums and nasal mucosa, and skin ecchymosis. In severe cases, liver function tests may reveal gastrointestinal bleeding.