How much creatinine is considered uremia? Patients should know

The higher the creatinine level, the more severely the patient's kidney function is damaged. If it reaches a certain level, it will develop into uremia. Generally speaking, when creatinine is >707umol/L, the patient's kidney function will be seriously disturbed and will develop into uremia.

1. Compensatory stage of renal insufficiency:

Assuming that the whole renal function is 100% when it is normal, the GFR in this stage is 35%~70% of the normal value (creatinine clearance is often used clinically to reflect GFR). Although the renal reserve capacity is reduced at this time, the renal function can still maintain the stability of the body's internal environment. There are no clinical symptoms and azotemia (ie, normal blood creatinine). However, it should be pointed out that if the stages are simply divided according to creatinine clearance, there may be overlaps between the stages. The blood creatinine value in this stage is: 133mm177umol/l.

2. Decompensated renal insufficiency:

Also known as the azotemia stage, or renal insufficiency for short, it is the prelude to chronic renal failure. At this time, the glomerular filtration rate is reduced to the normal 21%~35%, and the kidney's ability to maintain the body's internal environment is somewhat damaged. There may be varying degrees of azotemia, mild damage to the renal concentrating function (polyuria and nocturia), and mild anemia. Under normal circumstances, there are no obvious clinical symptoms and it is easy to be ignored. At this time, the creatinine value is: 177mm442umol/l.

3. Renal failure stage:

When GFR decreases to 11%~20% of normal, the body's internal environment has been abnormal for a long time and continuously, with significant azotemia and anemia; obvious concentration disorder (isotonic urine, nocturia), as well as water and electrolyte imbalance, such as mild or moderate metabolic acidosis, water retention, hypocalcemia, hyperphosphatemia, etc., generally without hyperkalemia. There may be mild gastrointestinal, cardiovascular and central nervous system symptoms. At this time, the creatinine value is: 442mm707umol/l.

4. Uremia stage:

That is, the late stage of renal failure. When the above renal failure stage develops further, the remaining GFR is only less than 10% of the normal level, and the uremia symptom group appears, which is manifested by more obvious clinical manifestations of renal failure and severe symptoms of various systems, especially gastrointestinal, cardiovascular and nervous system symptoms. Serum creatinine>707umol/L, severe imbalance of water and electrolytes, and often obvious metabolic acidosis.