What are the effects of Helicobacter pylori vaccine

Helicobacter pylori is closely related to gastritis, gastric ulcers, and even gastric cancer. This bacteria is very common throughout the world. Helicobacter pylori vaccine is a revolutionary success in the prevention of peptic ulcer disease. However, it should be noted that the current Helicobacter pylori vaccine is not very mature and its effectiveness needs further verification. Let’s take a look at some information about Helicobacter pylori vaccine.

Helicobacter pylori is a monopolar, multiflagellated bacterium with blunt-ended, spirally curved ends. Helicobacter pylori infection is closely related to major upper gastrointestinal diseases such as gastritis, peptic ulcers, and gastric cancer. Hp infection is still very common throughout the world, and the Hp infection rate in some developing countries and regions has not shown any signs of declining. Eradication of Hp can promote the healing of gastrointestinal ulcers and prevent their recurrence, which is a revolution in the etiology and treatment of gastrointestinal ulcers.

Whole-bacterial vaccines: can produce highly effective local mucosal immune responses. However, the antigen composition is relatively complex, and it has serious side effects and is expensive, making it unsuitable for large-scale cultivation and promotion. Subunit vaccine (genetically engineered vaccine): This is the main target of Ph vaccine. The advantage is that the recombinant protein antigen establishes an immune protection mechanism against antigens such as adhesins. Although it is still in the research stage, I believe that subunit vaccines (genetically engineered vaccines) will be the mainstream in the future.

Live vector vaccine: The development of live vector vaccine found that the heterologous live vector expression system still has technical deficiencies and the expression level is too low, making it difficult to obtain ideal results. DNA vaccine is a nucleic acid vaccine, which is mainly composed of protective antigens and eukaryotic expression vectors. So far, the research focus has been on DNA vaccines, which have the advantage of inducing a comprehensive immune response in the body, thereby preventing Ph.

Although the Helicobacter pylori vaccine has achieved certain effects, it is still relatively expensive because it has not been promoted on a large scale. In addition, the side effects of some vaccines have not been fully elucidated, which means that some people who want to be vaccinated will have to wait for some time. I believe that in the near future, we will have a vaccine against Helicobacter pylori.