What is ige antibody

More and more things in medicine are coming down from the altar and becoming known to people. But many times, when faced with the professional terms used in hospital examination forms, drug instructions, doctor's diagnosis letters, etc., people are still confused. What is IGE antibody? I guess not many friends know about this. Today, I will briefly introduce IGE antibodies to you!

Immunoglobulin IgE (a type of antibody in the human body) exists in the blood. It is the immunoglobulin with the lowest content in normal human serum and can cause type I hypersensitivity reactions. IgE has the immune function of binding to mast cells and alkaliphilic granulocytes.

High globulin levels are related to chronic liver disease and the body's immune system. Most of the immunoglobulins in human plasma are present in gamma globulin (γ-globulin). It can be divided into five categories, namely immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin D (IgD) and immunoglobulin E (IgE). Among them, IgG is the most important immunoglobulin, accounting for about 70% of human plasma immunoglobulin G, with a molecular weight of about 150,000 and a sugar content of 2-3%. IgG molecules are composed of 4 peptide chains. Among them, the peptide chain with a molecular weight of 25,000 is called a light chain, and the peptide chain with a molecular weight of 50,000 is called a heavy chain. The light chain and heavy chain are connected by disulfide bonds (—S—S—). Immunoglobulin is produced after the body is stimulated by antigens (such as pathogens). Its main function is to react immune to antigens and generate antigen-antibody complexes, thereby blocking the harm of pathogens to the body and making the pathogens lose their pathogenic effects. On the other hand, immunoglobulins sometimes play a pathogenic role. In patients with chronic hepatitis B, the ratio of white blood cells to globulin is inverted for a long time, and alert people to signs of liver cirrhosis.

The tail of the IgE antibody binds to the cell membrane of alkaliphilic cells and mast cells. When antibodies bind to antigens, alkaliphils and mast cells release substances such as histamine to promote the development of inflammation. This is also the antibody that triggers immediate allergic reactions.

Characteristics of IgE

IgE antibody is the Ig with the lowest content in normal human serum, and its serum concentration is extremely low, about 5x10^-5 mg/ml. Mainly secreted by plasma cells in submucosal lymphoid tissue. The molecular weight of IgE is 160kD. The important feature of IgE antibody is that it is a cytotropic antibody. Its CH2 and CH3 domains can bind to the high-affinity FcεR I on mast cells and alkaliphilic granulocytes. When it binds to the antigen that re-enters the body, it can cause type I hypersensitivity reaction. In addition, IgE antibodies may be related to the body's anti-parasitic immunity.

You never stop learning, but there are still three things you haven't learned. This is a common saying among the Chinese people. Ige antibodies may seem aloof, but once we understand them, they will not be mysterious anymore. It is recommended that everyone learn more relevant knowledge and exercise more. Friends in need can also go online to collect more knowledge to enrich their knowledge.