What is multidrug resistance

Now more and more people are beginning to realize that taking medicine, getting injections, or infusions when you are sick is a wrong solution. Because when the body takes in too much medicine, the virus will develop a certain degree of drug resistance and tolerance. Today we will take a detailed look at what multidrug resistance is, and hope it can help you.

Multidrug resistance (MDR) refers to the long-term exposure of tumor cells to a certain chemotherapy drug, which produces not only resistance to this chemotherapy drug, but also cross-resistance to multiple chemotherapy drugs with different structures and functions. This is the most important defense mechanism of tumor cells from the attack of chemotherapy drugs and is also one of the main reasons for the failure of chemotherapy. Multidrug resistance of tumor cells can be divided into natural resistance (resistance existing at the beginning of chemotherapy) and acquired resistance (induced by a chemotherapeutic drug during chemotherapy). It is currently believed that the occurrence of multidrug resistance is related to a variety of factors, such as resistance mediated by the multidrug resistance gene (MDR1) and its encoded glycoprotein (P-GP), increased expression of multidrug resistance-related protein (MRP) and lung resistance protein (LRP), enhanced activity of glutathione transferase (GST), changes in the activity of DNA repair and replication enzymes, DNA topology enzymes, and changes in calcium ion concentration. Let’s take a look at what multidrug resistance is? What kind of harm will it cause to the body.

Multidrug resistance (MDR) refers to resistance to one drug as well as resistance to other anti-tumor drugs with different structures and targets. Multidrug resistance is one of the important reasons for the failure of anti-infective drug treatment and tumor chemotherapy. The "super bacteria" that appeared in 2010 are also a type of multidrug resistance.

Causes and treatment

reason

Multidrug resistance arises from mutation or overexpression of molecules that deactivate drugs in cells.

The multidrug resistance of bacteria is mainly caused by the mutation of beta-lactamase, while the multidrug resistance of tumor cells is caused by the overexpression of proteins on the cell membrane that expel antitumor drugs, such as the overexpression of P-glycoprotein.

treat

There are several strategies to reverse and overcome drug resistance

1. Use drugs without cross-resistance

2. Inhibit the function of multidrug resistance proteins and overcome drug resistance

3. Reversal of drug resistance with verapamil (tumor cells)

I don’t know whether you can accurately grasp and understand the relevant knowledge about multidrug resistance that I introduced to you today. I hope that you will pay more attention to your physical health and future development when you are sick. It is recommended that you avoid intravenous infusions and frequent medication as much as possible to avoid drug resistance.