Uterine diseases trouble 8 types of people. To prevent endometrial cancer, you need to regulate your endocrine system

Nowadays, many women are troubled by uterine diseases, so what kind of women are most likely to be troubled by uterine diseases? So in response to everyone's questions, our editor will give you a brief introduction today. Next, let's listen to the editor's brief introduction to this issue!

1. Infertility

The high risk factor of endometrial cancer decreases with the increase of the number of births. Women with infertility caused by long-term anovulation are more likely to suffer from this disease than women who have given birth to one child. Patients with polycystic ovary syndrome are also prone to this disease for the same reason.

2. Obese people

Obesity is a manifestation of endocrine imbalance. A large amount of fat in the body increases the storage of estrogen. Fat also promotes the catabolic action of androgens, increases the estrogen content in the blood, and leads to endometrial hyperplasia and even cancer.

3. People with menstrual disorders, early menarche or delayed menopause

In the period before menopause, the woman is often in an anovulatory state, and the endometrium undergoes proliferative changes after being stimulated for a long time by a single estrogen without progesterone opposition.

4. Diabetes and hypertension

Some patients with diabetes, hypertension, etc. may develop polycystic ovary syndrome, atypical endometrial hyperplasia, and excessive estrogen levels in the body due to long-term pituitary abnormalities, which is also a cause of cancer.

5. People who take exogenous estrogen for a long time for various reasons

The use of exogenous estrogen alone without progestin antagonism may increase the risk of endometrial cancer, which is related to the dose and duration of estrogen use. If progestin is added to antagonize, the risk can be reduced.

6. Patients with uterine bleeding that has not been cured for a long time

Especially after menopause, uterine bleeding should be considered as a possibility of endometrial cancer, and a gynecological examination should be conducted as soon as possible to facilitate early detection and treatment.

7. Those with a history of X-ray exposure

Due to the influence of genetic factors, patients with endometrial cancer often have a family history or a history of cancer in close relatives. Therefore, those with a family history of endometrial cancer and a history of cancer in close relatives have an increased risk of the disease.

8. People with high income and higher education

Compared with the poorer people, the risk of endometrial cancer is twice as high, which may be related to excessive fat intake and less physical activity.

Regulate endocrine system to prevent endometrial cancer

Uterine cancer refers to the canceration of the endometrium, so the correct name should be endometrial cancer. It is one of the common malignant tumors of the female reproductive system and one of the health killers of women. It is more common in perimenopausal women over 50 years old. Endometrial cancer is an estrogen-dependent tumor, and its incidence is closely related to estrogen.

Women of childbearing age have strong ovarian function and normal menstrual cycles. With the development of follicles in each cycle, the estrogen level in the body gradually increases, and estrogen stimulates the endometrium to proliferate; after ovulation, the corpus luteum is formed, which can produce estrogen and progesterone.

Progesterone, also known as progesterone, can change the endometrium on the basis of hyperplasia to prepare for the implantation of the fertilized egg. At the same time, it also has the function of limiting the continued hyperplasia and growth of the endometrium, thereby preventing the endometrium from growing wildly like weeds. This characteristic of progesterone is of great significance in preventing endometrial cancer.

Women of childbearing age are in the stage of strong ovarian function. The endometrium is cyclically exposed to the effects of estrogen and progesterone in turn. The endometrium first shows proliferative changes, and after ovulation, it is exposed to the dual influence of estrogen and progesterone, causing secretory changes, which limits the continued proliferation and thickening of the endometrium.

Due to the protection of progesterone, women of childbearing age usually do not develop endometrial cancer. Therefore, progesterone is the protector of the endometrium.

After the age of 40, especially after the age of 45, women gradually enter menopause, and the ovaries begin to gradually enter the stage of functional decline from the stage of vigorous function. Specifically, the follicles in the ovaries gradually degenerate and gradually lose the ability to ovulate.

The ovaries cannot ovulate, which means that the corpus luteum no longer appears periodically and progesterone is no longer produced. Common dysfunctional uterine bleeding (called metrorrhagia in traditional Chinese medicine) in menopausal women is caused by the ovaries not being able to ovulate and the lack of progesterone in the body, which leads to disordered proliferation of the endometrium.

Long-term stimulation of the endometrium by a single estrogen in the body of menopausal women can cause the endometrium to grow uncontrollably, which can cause dysfunctional uterine bleeding at the mildest and endometrial cancer at the worst.

Therefore, regulating endocrine system, preventing and treating menopausal dysfunctional uterine bleeding have the effect of preventing endometrial cancer.

The method of endocrine regulation is very simple and the price is very low. The specific method of use is to adopt progestin cycle therapy: medroxyprogesterone (also known as medroxyprogesterone acetate) 6-10 mg (3-5 tablets), taken orally starting on the 15th day of the menstrual cycle, once a day, for 10 consecutive days, and menstruation will occur 3-7 days after stopping the drug.

Progestin cyclic therapy imitates the normal menstrual cycle and supplements progesterone in the second half of the menstrual period to transform the proliferative endometrium into secretory endometrium and inhibit the continued growth of the endometrium, thereby achieving the purpose of preventing endometrial cancer.

After menopause, the ovaries shrink and their functions fail, and they no longer secrete estrogen and progesterone. Logically, without estrogen stimulation, the endometrium should not become cancerous. But in reality, elderly women after menopause are still the target of endometrial cancer, and endometrial cancer occurs from time to time. Why is this?

There are three types of estrogens in the human body: estradiol (E2), estrone (E1) and estriol (E3). Estradiol is produced by the ovaries, about half of estrone is produced by the ovaries, and the other half is mainly synthesized by fat and other tissues. Estriol is a metabolite of estradiol and estrone and has weak biological activity.

After menopause, the ovaries fail and the estrogen in the body is mainly estrone synthesized by fat and other tissues. Therefore, excess fat in obese people will synthesize a large amount of estrone. Excess estrone stimulates the endometrium and can easily induce endometrial cancer.

It can be seen that the imbalance of sex hormones in menopausal women and the relatively increased estrogen levels are important factors in the development of endometrial cancer. Therefore, those with menstrual disorders, especially those with dysfunctional uterine bleeding, and those who are obese should pay great attention to endometrial cancer, and should go to the hospital for regular check-ups and cooperate with doctors for active treatment to prevent the occurrence of endometrial cancer.