What are the causes of colorectal cancer? 4 major causes are likely to cause colorectal cancer

Intestinal cancer is a general term, which includes colon cancer and rectal cancer. The prognosis of this disease is not good, and the survival rate is relatively low. It is recommended to focus on prevention. Among the factors of disease, the focus should be on diet, mainly referring to people who have a high-fat diet for a long time. The following is a specific introduction to the causes of intestinal cancer:

1. Environmental factors Studies have shown that among various environmental factors, diet is the most important, and the incidence of colorectal cancer is positively correlated with the high fat consumption in food. In addition, it may also be related to the lack of trace elements and changes in lifestyle habits.

2. Genetic factors There are reports of "familial colorectal cancer" both at home and abroad. The number of blood relatives of colorectal cancer patients who died of the disease is significantly higher than that of the general population. Some colorectal adenomas, such as multiple familial adenomatosis, are autosomal dominant genetic diseases with a family prevalence rate of up to 50%. If not treated, there is a possibility of colorectal cancer after the age of 10. Recently, some scholars have studied the relationship between tumor suppressor genes and colorectal cancer and found that the susceptibility and pathogenesis of colorectal cancer are both related to genetic factors.

3. Colon adenoma According to the research of autopsy materials from various places, the incidence of colon adenoma is quite consistent with that of intestinal cancer. According to statistics, the incidence of intestinal cancer in patients with one adenoma is 5 times higher than that in patients without adenoma, and the incidence of intestinal cancer in patients with multiple adenomas is 1 times higher than that in patients with a single adenoma.

4. Chronic colon inflammation: It is reported that the prevalence of intestinal cancer is positively correlated with the prevalence of schistosomiasis. It is generally believed that due to schistosomiasis, inflammatory changes in the intestines may lead to cancer in some cases. Other chronic inflammations of the intestines may also lead to cancer, such as ulcerative colitis, which has a 3% to 5% chance of cancer.

In fact, the specific causes of colorectal cancer are still not very clear. The above-mentioned are the most likely causes, which are summarized from the common characteristics of the vast majority of patients clinically. In addition to the above-mentioned factors, increasing age is also a key factor, which is a common point of all malignant tumors.