What are the early symptoms of lung cancer bone metastasis? Early symptoms of lung cancer bone metastasis

All diseases do not occur suddenly. There will be symptoms to remind us during the process of occurrence. Bone metastasis of lung cancer is no exception. However, many people are still not clear about the early symptoms of bone metastasis of lung cancer. In fact, the early symptoms of bone metastasis of lung cancer are not very obvious, so this needs to be understood more clearly.

Lung cancer is a malignant tumor that is very harmful to humans. It is very harmful to the human body, especially when lung cancer develops to the late stage, it will metastasize to other parts of the body, which will endanger life. Bone metastasis is one of the main manifestations of lung cancer metastasis. So what are the symptoms of early bone metastasis of lung cancer? Let's take a look at the following content introduction!

If lung cancer continues to develop, distant metastasis will occur, and the most common metastasis in the process of cancer cell metastasis is bone metastasis. Usually in the early stages, the symptoms of bone metastasis are not obvious. Pain is the most prominent symptom of bone metastasis in late-stage lung cancer.

Symptoms of lung cancer caused by bone metastasis include: bone pain and pathological fractures. Bone metastasis is caused by hematogenous spread. High-incidence sites include the pelvis, ribs, vertebrae and proximal long bones. Pain is the most common symptom of lung cancer. Periosteal inflammation and thickening are the root causes of pain. Usually bone metastasis occurs before bone pain occurs. 18.3% of patients with early non-small cell lung cancer develop bone metastasis, but only 27.2% develop bone pain, and most patients have no pain symptoms. Bones are a common site for lung cancer metastasis, and the incidence of lung cancer bone metastasis is related to the site and pathological type of the primary cancer. Adenocarcinoma has the highest incidence of bone metastasis, followed by small cell lung cancer and squamous cell carcinoma.

The lesions of bone metastasis are mainly multiple. The most common sites are: ribs, thoracic vertebrae, lumbar vertebrae, and pelvis; adenocarcinoma mainly metastasizes to the chest and pelvis.

Lung cancer bone metastasis is mainly adenocarcinoma, which often invades the ribs and thoracic vertebrae. The reason may be that adenocarcinoma often occurs around the lungs, which can easily cause direct invasion and involve the ribs and thoracic vertebrae.

In addition, tumor cells reach the bones through the blood circulation and tend to grow and multiply in the trunk bones containing red bone marrow, but rarely grow in the long bones of the limbs containing yellow bone marrow.

Bone metastasis of lung cancer is mostly osteolytic destruction, while small cell undifferentiated carcinoma and a few adenocarcinomas may show osteoblastic destruction. Among patients, 86% had osteolytic destruction, 6.9% had osteoblastic destruction, and 6.9% had mixed destruction. The incidence of hypercalcemia in primary lung cancer is 26%. Hypercalcemia in cancer patients is not mainly caused by increased osteoclast activity caused by bone metastasis, which causes calcium in the bones to enter the extracellular fluid. It may be caused by pTHrp secreted by the tumor and has nothing to do with bone metastasis. Therefore, the incidence of hypercalcemia is not high in lung cancer patients with bone metastasis.

Symptoms of bone metastasis from lung cancer: There are generally no symptoms in the early stages of bone metastasis, and bone isotope scanning can reveal diseased bones.

The symptoms of bone metastasis are related to the location and number of tumor metastases. For example, chest pain caused by rib metastasis of lung cancer is often manifested as pain localized in the chest wall with clear tenderness points.

Spinal cord metastases cause pain in the middle or lesion area of ​​the back, while bone metastases in the limbs or trunk cause localized pain in that area.