The best medicine for treating bone cancer

What are the best drugs for treating bone cancer? People will be very nervous when talking about bone tumors, because this is a very serious disease that can take a person's life. So we should learn more about the relevant knowledge. Once you have a bone tumor, it will be very painful. So we should use certain drugs to relieve the patient's pain. So what are the drugs that can treat and relieve bone tumors? Today we will make a relevant introduction, hoping to help patients with bone tumors.

1. Opioids

Opioids are a type of analgesic commonly used in clinical practice and are also the basis for analgesic treatment of bone tumors. They mainly include codeine, dihydrocodeine, hydromorphone, oxycodone, methadone, morphine, fentanyl, pethidine, etc. However, the therapeutic dose of opioids is large, and long-term use can cause side effects such as drowsiness, constipation, tolerance, and addiction.

2. Nonsteroidal anti-inflammatory drugs

The new cyclooxygenase-2 (COX-2) specific inhibitor has anti-tumor and anti-angiogenic effects. In the animal model of bone tumor pain, short-term use of this drug can slightly relieve severe bone pain, and long-term use can also reduce the destructive effects of tumor tissue and osteoclasts.

3. Bisphosphonates

Bisphosphonates were originally used to treat hypercalcemia caused by malignant tumors. These drugs can directly inhibit osteoclast activity and increase the pH value of the local microenvironment of tumor bone, thereby avoiding the activation of acid-sensitive ion channels. When analgesics and radiotherapy are not effective in treating bone tumor pain, bisphosphonates can be considered.

4. Osteoprotegerin (OPG)

Osteoprotegerin is a drug under development that binds and blocks RANK-L. Normally, RANK-L binds to CSF-1, stimulating the formation of osteoclasts and the activation of mature osteoclasts. OPG inhibits the activation of osteoclasts by RANK-L, thereby inhibiting bone destruction. It reduces the pain that occurs as a result, but cannot completely eliminate pain behavior and neurochemical changes.

The above are some medicines that can relieve the pain of bone tumor patients. I hope that the introduction of the above knowledge can be helpful to bone tumor patients. I hope that the above medicines can play an effective role in relieving the pain of bone tumor patients. I also hope that everyone will take effective measures in life to prevent the occurrence of bone tumors and avoid this disease from entangled themselves and causing themselves great pain and distress.