What causes cholangiocarcinoma? Pay attention to these aspects

Cholangiocarcinoma is a type of primary liver cancer, an adenocarcinoma that occurs in the epithelium of the secondary bile duct and its branches. Currently, the cause of cholangiocarcinoma may be closely related to chronic cholangitis, alcoholic liver disease, and certain chemical carcinogens. Bile duct, gallstones, bile duct cystic malformation, and congenital bile duct dilatation are also the main causes.

Cholangiocarcinoma also has different degrees of differentiation. Cancer cells easily infiltrate the portal area, as well as the blood vessels and nerves therein, and can form intrahepatic metastases along the lymphatic drainage pathway, or metastasize to local lymph nodes. Many patients are deeply tortured by this disease and know how to use some related methods for treatment. So what causes cholangiocarcinoma?
It is generally believed that the induction of this disease is related to long-term exposure to some chemicals, environmental pollution, bile duct disease, gallstones and other factors. It is generally believed that these factors are likely to lead to an increase in the incidence of this disease, so this aspect still needs to be taken seriously. And it is generally believed that this disease needs to consider some treatment measures.
The main cause of bile duct cancer is that many patients are caused by long-term smoking and alcoholism, because smoking and drinking are the main causes of bile duct cancer. Some are caused by patients not having a good living habit, so before treatment, quit smoking and drinking and develop a good living habit.
Bile duct and gallbladder stones
20% to 57% of patients with cholangiocarcinoma have gallstones, so it is believed that chronic irritation from stones may be a carcinogenic factor.
Ulcerative colitis <br/>It has been reported that the incidence of cholangiocarcinoma in patients with ulcerative colitis is 10 times higher than that in the general population. Patients often have a long history of colitis. Chronic bacteremia in the portal vein system of patients may be the cause of cholangiocarcinoma and PSC. The lesions often affect the entire colon. Ulcerative colitis-induced cholangiocarcinoma may be related to chronic portal vein bacteremia.
Cystic malformation of the bile duct Congenital bile duct dilatation <br/>The mechanism of bile duct cystic malformation leading to bile duct cancer is that some people believe that when the opening of the pancreatic duct into the bile duct is abnormally high, pancreatic fluid will flow back into the bile duct and cause malignant changes in the bile duct epithelium. Other factors that may lead to malignant changes include bile stasis, stone formation and chronic inflammation in the cyst cavity.
Patients with advanced cholangiocarcinoma are relatively weak. At this time, if they can actively receive treatment and appropriately enhance their resistance, their life span can be extended to a certain extent. Therefore, everyone must take effective treatment as soon as possible.