What are the pathological causes of testicular cancer

Testicular cancer is a disease that young men are prone to. Young men are in their prime, with elderly parents and young children to take care of. If they unfortunately get cancer, it will be a heavy blow to the patient and his family. So, what are the pathological causes of testicular cancer? Later, I will take you to learn about it together.

Testicular tumor is one of the common tumors in urology. It is almost always malignant, and there are three peaks in the age of onset: yolk sac tumor (infantile embryonal tumor) is the most common in infancy; various types of testicular tumors can be seen between the ages of 20 and 40, but seminoma is still the most common, and seminoma is the main tumor after the age of 70. Its cause is still unclear, and it is currently believed that its onset is related to both genetic and acquired factors. Among them, it is most closely related to cryptorchidism. The chance of cryptorchidism developing tumors is 10 to 14 times greater than that of normal people. Cryptorchidism in the abdominal cavity is higher than that in the groin. Testicular fixation does not reduce the incidence of malignant changes, but it can make tumors easier to detect.

The cause of the disease is still unknown, and it is currently believed that the onset of the disease is related to both genetic and acquired factors, among which cryptorchidism is the most closely related. The chance of developing tumors in cryptorchidism is 10 to 14 times greater than that in normal people, and cryptorchidism in the abdominal cavity is more common than in the groin.

Although many data suggest that the occurrence of testicular tumors may be related to testicular trauma, endocrine disorders, genetics and infection, there is a lack of sufficient evidence.

So far, the most convincing evidence is the relationship between incomplete testicular descent (cryptorchidism) and testicular tumors. A large amount of data confirms that the malignant transformation rate of cryptorchidism, especially abdominal cryptorchidism, is much higher than that of normal descended testicles. It is 3 to 14 times the incidence rate of normal people. It is currently believed that factors such as abnormal testicular germ cells, elevated temperature, blood supply disorders, endocrine disorders, and gonadal dysgenesis may be related to the malignant transformation of cryptorchidism.

The relationship between cryptorchidism and testicular tumors has attracted the attention of scholars from all over the world, who emphasize that testicular fixation before the age of 6 is an effective measure to prevent cryptorchidism from becoming malignant, and has achieved significant results. The incidence of cryptorchidism in China is similar to that in other countries, but the proportion of cryptorchid tumors is significantly higher than that in other countries, which may be related to the fact that testicular traction fixation has not yet been widely performed on cryptorchid children before school age in China.