What is the treatment for osteosarcoma

Although the incidence of osteosarcoma in my country is not high, this disease is a malignant tumor, and the harm it brings to patients and their families is beyond words. Therefore, patients must accept the reality and actively cooperate with the treatment. Patients do not know how to treat it, and they are inevitably uneasy. So let me introduce how to treat osteosarcoma.

1. Cryosurgery of osteosarcoma:

Liquid nitrogen has been used to cryotherapy various bone tumors in the past, and has achieved relatively ideal results. However, since the freezing range and temperature of liquid nitrogen are difficult to control well, it often leads to the expansion of the treatment range, causing necrosis of surrounding muscles and skin, or the tumor is not completely inactivated, resulting in the recurrence of some tumors after surgery. In recent years, with the invention of the argon-helium knife, it has the characteristics of multiple probes, high precision, rapid freezing, minimally invasive targeting, and accurate target ablation effect, and has shown satisfactory results in the treatment of bone tumors.

2. Radiotherapy for osteosarcoma:

Osteosarcoma is extremely malignant, and the 5-year survival rate of simple amputation is only 15% to 20%. In recent years, with the continuous emergence of new drugs, systemic chemotherapy plus postoperative radiotherapy has increased the 5-year survival rate to 60% to 70%. Osteosarcoma is not very sensitive to radiation, but some radiation-sensitive components in sarcoma can be killed by high-dose radiation. Radiotherapy is mainly used before and after chemotherapy, after surgery, and for patients who cannot or refuse surgery. If the patient's condition permits, chemotherapy and radiotherapy should be performed at the same time. The total dose of radiotherapy should be more than 60-100Gy, and the irradiation range should include the entire invaded bone and adjacent soft tissue. Osteosarcoma has a very high chance of lung metastasis, accounting for 50% of all osteosarcoma metastasis cases. For patients with lung metastasis, if it is a unilateral lung metastasis, 25Gy of unilateral whole lung irradiation can be given, and 15Gy of bilateral whole lung irradiation can be performed for bilateral lung metastasis, and then 20-25Gy is added to the residual tumor area. If the primary osteosarcoma is under control and the metastatic lesions in other parts of the body are single, surgical resection can be performed, followed by preventive treatment of the tumor bed.

3. Gene therapy for osteosarcoma: The abnormal expression of many oncogenes and tumor suppressor genes such as p53, Rb, and p16 in osteosarcoma provides a theoretical basis for the selection of targeted genes for gene therapy of osteosarcoma, especially in the treatment of osteosarcoma with lung metastasis, which has reached the stage of clinical trials. Now, a recombinant human adenovirus p53 gene has been generated.

Patients and their families have learned about the treatment methods of osteosarcoma. They should receive timely treatment without delay, otherwise the condition will become more and more serious. I hope my answer is helpful to you and I wish you a speedy recovery.