How long do people with osteosarcoma usually live?

Osteosarcoma is the most common type of malignant bone tumor. It develops from the mesenchymal cell line. The rapid growth of the tumor is due to the direct or indirect formation of tumor bone-like tissue and bone tissue during the cartilage stage. Under the influence of external factors (such as viruses), the weight-bearing bones of the lower limbs cause cell mutations, which may be related to the formation of osteosarcoma. How long do people with osteosarcoma usually live?

Typical osteosarcomas originate from the bone, while another completely different type of osteosarcoma is the osteosarcoma that is parallel to the bone cortex and originates from the periosteum and nearby connective tissue. The latter is less common and has a slightly better prognosis.

The prominent symptom of osteosarcoma is pain at the tumor site, which is caused by the tumor tissue eroding and dissolving the bone cortex.

1. Pain

Pain of varying degrees at the tumor site is a very common and obvious symptom of osteosarcoma. It is caused by the expansion of the tumor tissue destroying the bone cortex and stimulating the periosteal nerve endings. The pain may develop from intermittent in the early stage to continuous after a few weeks, and the degree of pain may increase. Pain in the lower limbs may cause pain-avoiding claudication

2. Lump

As the disease progresses, local swelling may occur, and a lump may be felt at the painful part of the limb, accompanied by obvious tenderness. If the lump grows rapidly, the lump can be found from the appearance. The skin temperature on the surface of the lump increases and the superficial veins are exposed. The surface of the lump and the nearby soft tissue may have varying degrees of tenderness. The hardness of the lump varies due to the different degrees of ossification. As the lump grows, it causes limited joint movement and muscle atrophy.

3. Limping

Analgesic claudication caused by limb pain worsens as the disease progresses. Patients with long-term illness may experience limited joint movement and muscle atrophy.

4. General condition

When the diagnosis is confirmed, the general condition is generally poor, manifested by fever, malaise, weight loss, anemia and even exhaustion. In some cases, the tumor grows very quickly and metastasizes to the lungs at an early stage, causing the general condition to deteriorate. Pathological fractures at the tumor site make the symptoms more obvious.

Osteosarcoma is still a malignant tumor with a high mortality rate in children and adolescents, but early detection and timely treatment have greatly improved the survival rate of the disease.

After osteosarcoma is diagnosed by pathology, early chemotherapy or radiotherapy begins. Resection of tumor tissue is an important step in the treatment of osteosarcoma. With the improvement of tumor surgical technology and the development of implant research, limb preservation therapy has shown a good treatment prospect. Consolidation chemotherapy or radiotherapy after tumor tissue resection is very important for controlling tumor metastasis and improving survival rate.

Immunotherapy consists of intravenous infusion of lymphocytes or interferon and transfer factor, but the efficacy is still uncertain.

How long do people with osteosarcoma usually live? In cases of osteogenic osteosarcoma, elevated levels of bone-derived alkaline phosphatase in the blood can be found in the early stages, which is related to the osteogenesis of the tumor. Pathological diagnosis is the basis for treatment. When considering the diagnosis of osteosarcoma, a biopsy is performed to confirm the pathological examination as soon as possible, which is of great significance for a clear diagnosis and treatment.