Method for selecting medication for osteosarcoma

After suffering from osteosarcoma, patients will want to know whether the disease can be cured. Among the treatment methods, drug treatment is relatively less painful. Early osteosarcoma patients can be treated conservatively with drugs. However, the choice of drugs for the treatment of osteosarcoma should be cautious to prevent side effects. There are mainly the following methods of drug treatment for patients with osteosarcoma.

High-dose multi-drug combination chemotherapy: After more than 30 years of extensive clinical practice, it has been proven to be a chemotherapy method with good effects. Commonly used drugs: cyclophosphamide, ifosfamide, vincristine, doxorubicin, bleomycin, etc.

Neoadjuvant chemotherapy: refers to chemotherapy that should be performed for at least 2 courses before surgery. The role of preoperative chemotherapy is to fully shrink and necrotize the primary tumor, shrink or eliminate the reaction area around the tumor, eliminate satellite lesions or skipping lesions, help to completely remove the local tumor and strive for limb preservation; eliminate the possible tiny metastatic lesions in the lungs as much as possible, and theoretically reduce the drug resistance of the tumor; based on the initial chemotherapy response, test the sensitivity of chemotherapy drugs in vivo, adjust and improve the postoperative adjuvant chemotherapy plan; start drug treatment as early as possible, which can more effectively eliminate metastatic lesions, shrink the primary lesion, postpone the operation time, and have enough time to prepare for surgery. Continue chemotherapy after surgery to prevent tumor recurrence and metastasis. Neoadjuvant chemotherapy with multiple drugs has resulted in no recurrence for 5 years, and the survival rate has risen to 82%.

Currently, many neoadjuvant chemotherapy regimens include the combined use of multiple drugs for more than 8 weeks, followed by tumor resection and additional chemotherapy for 3 to 8 months after surgery. Commonly used drugs include doxorubicin and cisplatin, with increased methotrexate doses. The latest studies have shown that the addition of cyclophosphamide to chemotherapy regimens can significantly increase tumor necrosis rates and patient survival rates.