Family hereditary endometrial cancer

Is endometrial cancer hereditary? Endometrial cancer originates from the malignant tumor of the endometrial glands, also known as uterine body cancer, and most of them are adenocarcinomas. It is one of the three major malignant tumors of the female genitals, with a high incidence age of 58 to 61 years old, accounting for about 7% of the total number of female cancers and 20 to 30% of female reproductive tract malignant tumors. The genetic factors of the disease account for about 20% of endometrial cancer patients with a family history.

Since endometrial cancer is hereditary, let's take a look at the manifestations of endometrial cancer:

1. Uterine bleeding:

Irregular vaginal bleeding before and after menopause is the main symptom of endometrial cancer. It is usually a small to moderate amount of bleeding, and rarely a large amount of bleeding. Not only are younger or near-menopausal patients prone to mistaking it for irregular menstruation and not seeking medical treatment in time, but even doctors often neglect it. Some individuals also have delayed menstrual cycles, but the symptoms are irregular. Postmenopausal patients often present with continuous or intermittent vaginal bleeding. Endometrial cancer patients generally do not have contact bleeding. Late bleeding may be mixed with rotten meat-like tissue.

2. Pain:

Usually it does not cause pain. Advanced cancer infiltrates surrounding tissues or compresses nerves, causing pain in the lower abdomen and lumbosacral region, which radiates to the lower limbs and feet. When the cancer invades the cervix, blocks the cervical canal and causes pyometra, there will be distending pain and cramp-like pain in the lower abdomen.

3. Vaginal discharge:

Because adenocarcinoma grows in the cervical cavity, the chance of infection is less than that of cervical cancer, so in the early stage, there may be only a small amount of bloody leucorrhea, but in the late stage, infection and necrosis occur, and a large amount of foul-smelling pus and blood-like fluid is discharged. Sometimes the discharge may contain small fragments of cancerous tissue. If pus accumulates in the cervical cavity, it will cause fever, abdominal pain, and leukocytosis, and the general condition will deteriorate rapidly.

4. Pelvic examination:

There is no special feature in the early stage. In the late stage, the uterus becomes enlarged and full. When there is pyocerebus, the uterus becomes significantly enlarged and cystic. In the late stage, metastatic nodules can be felt beside the uterus.

5 Systemic symptoms:

Patients with advanced endometrial cancer may feel an enlarged uterus in the lower abdomen, or adjacent tissues and organs may cause swelling and pain in the lower limb on that side, or compression of the ureter may cause hydroureteral pelvis or kidney atrophy on that side; or systemic symptoms may occur, such as anemia, weight loss, cachexia, fever, and systemic failure.