Research progress on the etiology of gallbladder cancer

Among the malignant tumors of the gallbladder, gallbladder cancer ranks first, and others include sarcoma, carcinoid, primary malignant melanoma, giant cell adenocarcinoma, etc. Primary gallbladder cancer is relatively rare clinically, and according to domestic reports, it only accounts for about 1% of all cancers. So what are the results of the research on the cause of gallbladder cancer?

The cause of gallbladder cancer is still unclear. Clinical observation shows that gallbladder cancer often coexists with benign gallbladder diseases, most commonly with gallstones. Most people believe that chronic stimulation of gallstones is an important pathogenic factor. Moosa pointed out that 3.3% to 50% of people develop gallbladder cancer 5 to 20 years after "hidden stones". Domestic bulk data report that 20% to 82.6% of gallbladder cancers are accompanied by gallstones, while foreign reports are as high as 54.3% to 100%. The occurrence of cancer is closely related to the size of the stones. The probability of cancer is closely related. The probability of cancer in patients with stone diameter less than 10mm is 1.0, the probability of cancer in patients with stone diameter of 20-22mm is 2.4, and the probability of cancer in patients with stone diameter above 30mm can be as high as 10%. Some people have suggested that the occurrence of gallbladder cancer may be related to the malformation of the junction of the lower end of the common bile duct and the main pancreatic duct. Because of this malformation, pancreatic juice enters the bile duct, which increases the concentration of pancreatic juice in the bile, causing chronic inflammation of the gallbladder, mucosal changes, and finally cancer. The cause of gallbladder cancer is still unclear.
It has been reported that chronic inflammatory diseases of the intestine, chronic typhoid infection of the gallbladder, syndrome, etc. are related to the occurrence of gallbladder cancer. Through the explanation of the above experts, we have a detailed understanding of the causes of gallbladder cancer. In addition, we also know that this disease can generally be divided into benign and malignant. Once it occurs, it must be treated as soon as possible to avoid the risk of cancer. In addition, we should strictly regulate our diet and eat more anti-cancer foods.