Case of cure of advanced ovarian cancer

From some cases, we can easily see that the number of deaths caused by ovarian cancer each year accounts for the first place among all kinds of gynecological tumors, which poses a serious threat to women's lives. Usually, its treatment is mainly surgical resection, but due to the lack of effective diagnosis methods in the early stage of ovarian cancer, in the late stage, the surgical effect is often not good. Next, let's take a look at the following 41 cases of ovarian cancer patients and see if they have achieved good short-term results.

Materials and methods, treatment methods

Before the operation, routine blood test, coagulation time, chest X-ray, electrocardiogram, B-ultrasound and other laboratory tests were performed; 10 mg of diazepam was injected intramuscularly 30 minutes before the operation. If cisplatin chemotherapy was chosen, intravenous hydration therapy was performed after the operation.

The patient was asked to lie flat on the operating table, the groin and perineum were prepared, the surgical site was fully exposed, intravenous access was established, and the femoral artery was cannulated percutaneously. The abdominal aorta-iliac artery was first performed, and then bilateral internal iliac artery angiography was performed. Dissolve 50 mg of pirarubicin in 60 ml of 5% glucose injection, 60 mg of cisplatin, and 400 mg of cyclophosphamide in 60 ml of 0.9% sodium chloride solution, and then dilute them through the catheter internal iliac artery for interventional chemotherapy. If bilateral internal iliac artery chemotherapy is required, the above drugs can be divided into two parts and injected bilaterally. During the operation, pay attention to ECG monitoring and observe changes in the patient's vital signs.

After the operation, the patient must rest in bed, press the puncture site with a sandbag for 6 hours, and immobilize the lower limb on the intubated side for 24 hours. Pay attention to the bleeding at the puncture site, the color of the dorsalis pedis artery and skin on the operated side, and whether there is pain in the lower limb. Sodium thiosulfate is dripped intravenously to alkalinize the urine, so that the patient's urine volume is greater than 150 ml per hour.

Postoperative follow-up: Because tumor chemotherapy is a chronic process, it requires the active cooperation of patients to achieve satisfactory results. The first three courses of interventional chemotherapy are once a month, which is changed to once every 3 months after the condition stabilizes, and once every 0.5 years after 2 years. Follow-up observation is performed after 4 years.

Check blood routine once a week. If the white blood cell count is less than 3.0×109 per liter and the platelet count is less than 80×109 per liter, give hematopoietic drugs and strengthen nutrition to ensure the smooth progress of chemotherapy.

Regular B-ultrasound examinations should be performed to observe whether the mass shrinks or increases so as to adjust the treatment medication.

Pay attention to the combination of work and rest, ensure adequate sleep, and maintain a good attitude.

result

2 Treatment effect After 3 courses of treatment, 41 cases of abdominal pain, abdominal distension, and ascites disappeared, and 35 cases of tumors shrank by B-ultrasound examination. Among them, PR was achieved in 16 cases and MR was achieved in 19 cases. 2.2 Adverse reactions and measures

During the injection of pirarubicin, 7 patients developed symptoms such as facial flushing, dizziness, palpitations, and tingling in the perineum. After oxygen inhalation, intra-catheter injection of 2% lidocaine 50 mg, and slowing of the drug injection speed, the symptoms disappeared in about 10 minutes.

Bleeding at the puncture site occurred in 1 case.

Two cases developed abdominal pain, nausea, and vomiting. After a push injection of several mg of ondansetron and acupuncture at Neiguan, Hegu, and Zusanli, the symptoms were relieved after 1 hour.

One patient developed palpitations and chest tightness after the operation. After ECG monitoring, oxygen inhalation, and myocardial nutrition, the symptoms disappeared after 48 hours.

Two patients had postoperative abdominal pain and a 12-hour urine output of less than 800 ml. Furosemide was given iv and fluid was supplemented to make the urine output greater than 150 ml per hour.

Direct injection of high-concentration anticancer drugs into the tumor blood supply artery can increase the drug concentration inside the cancer. The drug concentration inside the cancer after intra-arterial administration is many times higher than that after systemic intravenous administration and many times higher than that after intraperitoneal administration. Chemotherapy through the tumor blood supply artery is beneficial to improve the efficacy and shorten the course of treatment. After intra-arterial administration, the drug concentration in peripheral blood during the same period is determined to be intravenous administration for intra-arterial administration and intraperitoneal administration for intra-abdominal administration. Therefore, the drug concentration in the tumor is high during intra-arterial administration and lasts for a long time, while the systemic toxic side effects are mild, and the symptoms of postoperative nausea and vomiting are significantly less than those of systemic administration. Interventional chemotherapy has high efficacy and few side effects, and patients are willing to accept it, which has broadened the treatment channels for patients with advanced ovarian cancer.