Is there a high chance of hereditary gastric cancer?

The incidence of gastric cancer is very high in my country, and there is a phenomenon of family clustering. Regarding the question of whether gastric cancer is hereditary, it is generally believed that although the role of genetic factors in the development of gastric cancer is not as important as that in colorectal cancer, a family history of gastric cancer may still be a risk factor. Because gastric cancer has a clear tendency to cluster in families, the family incidence rate is 2 to 3 times higher than that of the general population.

Genetic risk: Gastric cancer patients have obvious family clustering. Investigations have found that the risk of first-degree relatives (i.e. parents and siblings) of gastric cancer patients getting gastric cancer is three times higher than the average of the general population. A well-known example is Napoleon's family. His grandfather, father and three sisters all died of gastric cancer. A total of seven people in the family, including himself, suffered from gastric cancer.

Prevention and treatment principles: Risk factors for gastric cancer include lack of physical exercise, mental depression, smoking, preference for smoked foods, preference for high-salt diets, excessive meat intake, Helicobacter pylori infection, gastric ulcers, etc. However, preference for fungi and fresh fruits are protective factors for gastric cancer. It is worth noting that the familial clustering of gastric cancer may be related to co-infection with Helicobacter pylori. People with a family history of gastric cancer should go to the hospital to monitor for infection with the bacteria, and seek timely treatment if they are infected. Avoid moldy food. In our daily lives, we often encounter moldy and spoiled foods. Mold is caused by contaminated molds. Some of the molds are toxin-producing fungi, which are strong carcinogens. At the same time, some foods will produce a large amount of nitrites and secondary amines under the action of toxin-producing fungi. After entering the body, under certain conditions, they can synthesize nitrosamine compounds and cause cancer.