Does gallbladder cancer cause vomiting

At present, the cause of gallbladder cancer is still not completely clear. Most people believe that it is caused by a combination of factors, which may include mechanical stimulation of stones, inflammation, abnormal cholesterol metabolism and stimulation of bile, which cause mucosal hyperplasia and degeneration, and then cancer. 75% of patients with gallbladder cancer also have gallbladder stones, and 10% of patients with gallbladder stones suffer from gallbladder cancer, and the incidence rate is higher than that of patients without stones. As for whether there is any influence of certain chemical carcinogens, there is not enough evidence.

1. Risk factors Being familiar with the risk factors of gallbladder cancer can improve the rate of early diagnosis.

① Middle-aged and elderly female patients with gallstones over 50 years old; ② Those with a long course of disease and a history of gallstones for more than 5 years; ③ Patients with gallstones whose B-ultrasound shows localized thickening of the gallbladder wall; ④ Gallstones with a diameter > 2 cm or impacted stones in the gallbladder neck; ⑤ Patients with gallstones whose pain in the gallbladder area has recently become persistent, and who have obvious symptoms of digestive dysfunction, and who are emaciated and weak; ⑥ Patients with a single gallbladder polyp ≥ 10 mm in diameter or < 10 mm but multiple; ⑦ Non-functional gallbladder, porcelain gallbladder, and gallbladder wall calcification that develops into porcelain gallbladder; ⑧ Abnormal bile and pancreatic duct confluence; ⑨ Exposure to some carcinogens, such as methylcholanthrene.

2. Relationship between cholelithiasis, chronic cholecystitis and gallbladder cancer

(1) According to foreign reports, 80% of gallbladder cancer and gallstones coexist, while in China, the coexistence rate is 70%.

(2) The larger the stone diameter, the higher the incidence of gallbladder cancer.

(3) The risk of developing gallbladder cancer in people with gallstones is 6 to 15 times higher than that in people without gallstones.

(4) The development process of gallbladder cancer is speculated to be: cholelithiasis/cholecystitis → hyperplasia of the gallbladder mucosal epithelium and the appearance of atypical hyperplasia. Mild cases lead to carcinoma in situ, while severe atypical hyperplasia leads to invasive cancer.

(5) During bile metabolism, cholic acid, a product of chenodeoxycholic acid, is a carcinogen. The level of cholic acid in patients with gallbladder cancer increases. Some people also believe that cholesterol and bile salts in bile can become carcinogens under the influence of infection, especially when infected with anaerobic bacteria Bacillus subtilis. This may be one of the reasons for stimulating the gallbladder mucosa to produce cancer.