What is the cause of bladder cancer

In recent years, bladder cancer has become one of the major diseases that endangers society and human health, and it has brought great pain and distress to humans. In order to reduce the incidence of bladder cancer, we humans should understand the causes of bladder cancer:

Jobs involving long-term exposure to aromatic substances

Workers working in the dye, leather, rubber, and paint industries may have a high incidence of bladder tumors.

Smoking

It is also a reason for increasing the incidence of bladder tumors. Recent studies have shown that smokers increase the metabolism of tryptophan, a carcinogen, in their urine by 50%. When smoking stops, tryptophan levels return to normal. 40% of male and 31% of female bladder cancer patients may be caused by smoking. Hoover et al. reported that as the number of smokers increases in the population born successively, the incidence of bladder cancer is also increasing, and certain occupational pollution is associated with an increased risk of bladder cancer. Dyes, rubber, leather, printing, paint, petroleum and other organic chemical industries are particularly dangerous, and their common feature is the presence of aromatic amines, that is, smoking and occupational pollution together have an additive effect on the occurrence of bladder cancer.

Abnormal tryptophan metabolism in the body

Abnormal metabolism of tryptophan can produce some metabolites, such as 3-hydroxy-2-aminoacetophenone and 3-hydroxy-o-aminobenzoic acid, which can directly affect the synthesis of RNA and DNA in cells. These metabolites are excreted into the bladder through the action of the liver and have carcinogenic effects after being acted on by β-glucuronidase.

Chronic irritation of the bladder mucosa

Chronic local irritation of the bladder wall, such as chronic infection, bladder stones and urinary tract obstruction, may be factors that induce cancer. Cystitis glandularis and leukoplakia are considered to be precancerous lesions that can induce cancer.

drug

Taking large amounts of phenacetin has been shown to cause bladder cancer.

Parasitic diseases

If it occurs in the bladder, it can also induce bladder cancer.

The above are the causes of bladder cancer. Expert Tips: If you have symptoms of disease, do not delay diagnosis and go to a regular hospital for treatment in time to avoid delaying the disease and causing serious consequences. If you have other questions, please consult our online experts or call for consultation.

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