Relationship between urine protein and creatinine

Eating and sleeping are normal physiological needs of the human body, and the food people consume will be excreted from the body in the form of feces, urine and sweat. Therefore, when we go to the hospital for a physical examination, we can use urine tests to analyze the content in the urine to see if there are any abnormal symptoms in the human body. In the urine test report, urine protein and creatinine are two very important detection indicators. So what is the relationship between urine protein and creatinine?

The determination of the urine protein to creatinine ratio is a new and reliable method for monitoring the excretion of urine protein. There is often a certain amount of protein in the blood that is indispensable to human life activities. Some of the protein is filtered into the urine in the glomeruli of the kidneys, but is absorbed back into the blood in the renal tubules. Therefore, if there is an obstruction in the kidneys and ureters, a large amount of protein will leak out and become proteinuria. There is a trace amount of protein in the urine of normal people, which is qualitatively negative within the normal range and recorded as (-). When the protein content in urine is more than 0.15g/24h, it is called proteinuria, and routine urine tests may show positive results. Persistent positive urine protein often indicates kidney disease.

This is because the determination of the urine protein to creatinine ratio can reliably reflect the amount of urine protein in 24 hours; it is fast, simple and accurate, and is an ideal indicator for the qualitative and quantitative diagnosis of proteinuria and follow-up in clinical practice. It can replace the traditional method of 24-hour urine protein quantification.

Normal range: less than 0.10 to 0.20

The significance of urine protein/creatinine ratio

The 24-hour urine protein determination method most commonly used in clinical practice has a high accuracy (normal value is less than 0.15g/24h), but the urine sample collection process is long and is greatly affected by patient compliance, especially in young children, where it is difficult to collect 24-hour urine samples. Therefore, it is much more convenient to measure the urine protein/creatinine ratio in real time to predict the amount of urine protein in 24 hours.

Urine protein/creatinine ratio and 24-hour urine protein

The urine protein to creatinine ratio has a reliable correlation with the 24-hour urine protein. It can accurately predict the 24-hour urine protein excretion. Compared with the traditional 24-hour urine protein quantification, it is fast, simple and accurate. It is an ideal indicator for qualitative and quantitative diagnosis of proteinuria and follow-up in clinical practice.