Is cholestatic liver disease serious?

Liver disease is a relatively serious disease because the liver is the main organ for detoxification in the human body. If the liver is diseased, many toxins in the human body will not be excreted in time, and over time it will affect other organs of the human body. Cholestatic liver disease is a relatively common type of liver disease, and its main manifestation is bile duct obstruction in patients. So, is cholestatic liver disease serious?

Is cholestatic liver disease serious?

Cholestatic liver disease is generally a disease caused by congenital bile duct obstruction in babies, which results in poor bile excretion in babies, liver damage, yellowing of the skin, jaundice, nausea, vomiting, inability to eat, etc. Cholestatic liver disease is quite serious and can cause cirrhosis. First check, then treat. The sooner the biliary atresia surgery is performed, the better.

Cholestatic liver disease hazards

Cholestatic liver disease may develop into liver cancer. If cholestasis obstruction cannot be relieved for a long time, bile will repeatedly stimulate liver cells and may develop into cirrhosis and eventually turn into liver cancer. However, the possibility of cholestatic liver disease leading to cancer is relatively small. Identifying the cause of cholestasis in the early stages of cholestasis and eliminating the cause can reduce the risk of cancer.

Cholestatic hepatitis (intrahepatic cholestasis) refers to a disorder in cellular bile secretion caused by various reasons. The abnormal functions of organelles such as bile capillaries, cytoskeleton and Golgi apparatus reduce bile secretion, resulting in the inability of normal amounts of bile to reach the duodenum and causing bile components (conjugated bilirubin, bile acid, cholesterol and alkaline phosphatase, etc.) to reflux into the blood. Clinically, it is a group of symptoms and signs with jaundice and itching, accompanied by increased serum conjugated bilirubin, cholesterol, bile acid, ALP, 5-nucleotidase and albumin. Common diseases include viral cholestatic hepatitis, drug-induced cholestatic hepatitis and primary biliary cirrhosis.

Cholestatic liver disease is a common type of liver disease and also one of the most harmful types, so it must be treated early. During the treatment period, patients should also be given a good diet adjustment, eat less high-fat foods, eat more vegetables and fruits, and their daily diet should be light. Spicy and irritating foods are prohibited.