Is pemphigus vulgaris easy to treat if discovered early?

Pemphigus vulgaris is an extremely common disease and a manifestation of viral infection. It has a great impact on the health of the body and causes severe pain in the affected area. Moreover, this disease is highly contagious and can easily spread among family members, expanding the scope of viral infection. The key to treatment is to detect the disease early. Let’s take a look at whether pemphigus vulgaris is easy to treat if it is detected early.

This disease is an autoimmune disease. Antibodies can be detected at the lesions, and antibodies against epidermal cell spines can also be detected in the blood.

Treatment options for pemphigus vulgaris

1. Supportive therapy should include a high-protein, high-vitamin diet and intravenous supplementation. Patients with systemic failure require multiple small-scale blood transfusions.

2. The initial dose of adrenal cortical hormone prednisone is 120-180mg/d; or 60-100mg/d. The initial dose can be reduced gradually after no new lesions appear for 1-2 weeks, by 5mg each time, and once every 1-2 weeks. If it is lower than 30mg/d, the dose should be reduced with caution until 10-15mg per day is the maintenance dose. For patients with severe pemphigus, pulse therapy and intermittent dosing can be used. That is, give high doses of adrenal cortical hormones until the condition stabilizes (about 10 weeks), gradually reduce the dose to 30 mg/d of prednisone, and then use the treatment of giving the drug every other day or giving the drug for 3 days and resting for 4 days.

3. Combined treatment with immunosuppressants such as cyclophosphamide, azathioprine or methotrexate and adrenal cortical hormones such as prednisone can reduce the dosage of the latter and thus reduce side effects.

4. Antibiotics: Add antibiotics to prevent concurrent infection.

5. For local medication, for those with oral erosion and pain, apply 1%-2% tetracaine solution before eating, and gargle with 0.25% tetracycline or chloramphenicol to help maintain oral hygiene. Topical application of corticosteroid ointment preparations can promote the healing of oral wounds.

6. Enzyme inhibitors: Corresponding inhibitors of various proteolytic enzymes have been shown to be able to resist the occurrence of acantholysis, but there are no reports of successful clinical applications.

7. For the spleen deficiency and damp-heat type, you can choose Buzhong Yiqi Decoction, Qingpi Chushi Drink, Wuling Powder, etc. with additions and subtractions; for the heat toxic and fiery type, you can choose Huanglian Jiedu Decoction, Qingwen Duruan, Qingying Decoction, Ganlu Xiaodu Dan, Yunu Jian, etc. with additions and subtractions.