Will dysplastic nevus be passed on to the next generation?

Dysplastic nevus is a common nevus. Many times, during medical examinations, dysplastic nevi and melanoma are very similar. So, will dysplastic nevi be passed on to the next generation? Experts say that dysplastic nevi actually have a certain genetic basis. If one of the parents has a dysplastic nevus, it is likely to be passed on to the next generation.

Dysplastic nevus, also known as dysplastic nevus syndrome and BK syndrome, is often mistaken for superficial disseminated malignant melanoma clinically. This disease has a certain relationship with the occurrence of malignant melanoma and tends to run in families. About 1/3 to 1/5 of dysplastic nevi have histology similar to malignant melanoma. The differentiation disorder of dysplastic nevus may have a certain genetic basis. The damage can occur anywhere on the body surface, and excision is the preferred treatment method.

Pathogenesis

1. Causes of disease

Can appear in childhood. About 1/3 to 1/5 of dysplastic nevi have histology similar to malignant melanoma. Cell atypia and proliferation are somewhat correlated with sun exposure. In addition, some studies believe that. Dysplastic nevi are associated with partial deletions of chromosome 11 and testicular germ cell tumors. Familial malignant melanoma and dysplastic nevi are also associated with endocrine glandular syndrome and autoimmune polyglandular syndrome. The above correlations cannot be fully determined.

The differentiation disorder in dysplastic nevi may have a certain genetic basis, and endogenous hormones and the external environment promote the development of the disease. Genetic analysis of families susceptible to malignant melanoma suggests that it is an autosomal dominant disease, and the abnormal gene may exist at 1p35 or 9p21, leading to cell cycle abnormalities.

2. Pathogenesis

The pathogenesis is still unclear. The abnormal gene may exist at 1p35 or 9p21, leading to mutation of the cell cycle enzyme p16/CDKN2A and causing abnormal cell differentiation. In addition, excessive photochemical products induced by ultraviolet light in dysplastic nevi can cause malignant transformation of cells.

Clinical manifestations

1. Lesions can occur anywhere on the body surface, but are most common on the trunk, followed by the limbs and then the face.

2. Lesions are single or multiple, usually larger than naevus cell nevi, and some may exceed 7 mm in diameter. The center is often raised, hairless, of varying sizes, with irregular or unclear edges and uneven color depth.

3. When the lesions are multiple, they may develop into malignant melanoma, but if they are single, they have nothing to do with malignant melanoma.

In typical cases, pathological examination can confirm the disease without difficulty, but when there is a tendency for superficial skin spread, it is difficult to make a decision.