Aminophenol

Aminophenol is mainly used in many chemical plants, especially in some places that are not related to human diet, but it also needs to be processed before it can become some items related to the human body. During use, you need to be careful to wear gloves and protective clothing, because it is dangerous and may cause harm to the human body imperceptibly.

1. Used in the production of dyes such as sulfide blue FBG and weak acid yellow 5G, the manufacture of drugs such as paracetamol and clofibrate, and also used in the preparation of developers, antioxidants, etc. 2. This product is an intermediate for fine chemicals such as medicines and dyes. Used in the production of paracetamol, azo dyes, sulfur dyes, acid dyes, fur dyes, as well as developers, antioxidants and petroleum additives. 3. Inspection fee. Determination of copper, iron, magnesium, vanadium, nitrite and cyanate. Antioxidant. Organic synthesis. Photographic developer. 4. Used as analytical reagents, antioxidants, oil additives, dyes, medicines, and photographic developers. 5. Mainly used in dye industry to manufacture azo dyes, sulfur dyes, acid dyes and fur dyes (such as fur brown P). In the pharmaceutical industry, it is used to manufacture drugs such as paracetamol and clofibrate. It is also used to manufacture developers, antioxidants and petroleum additives. In the cosmetics industry, it is used in hair dye formulations (as a complementary dye). 6. Used in the manufacture of dyes, drugs and plastic curing agents, etc. [20]

R20/22: armful by inhalation and if swallowed. Harmful by inhalation and if swallowed.

R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

R68: Possible risk of irreversible effects.

Security Terminology

S28A:;S36/37:Wear suitable protective clothing and gloves.

S60:This material and its container must be disposed of as hazardous waste.

S61:Avoid release to the environment. Refer to special instructions / safety data sheets. Avoid release to the environment. Refer to Special Instructions/Safety Data Sheet.

CAS No.: 123-30-8

MDL No.: MFCD00007869

EINECS number: 204-616-2

RTECS No.: SJ5075000

BRN No.: 385836

PubChem Number: 24861974

Toxicology Data

1. Acute toxicity[7]

LD50: 375 mg/kg (oral in rats); 420 mg/kg (oral in mice); 10000 mg/kg (oral in rabbits); >10 g/kg (dermal in rabbits).

LC50:>5mg/m3 (rat inhalation, 1h)

2. Irritation[8]

Rabbit percutaneous administration: 12500 μg (24h), mild irritation.

Rabbit eye: 100 mg, mild irritation.

3. Mutagenicity[9]

Microbial mutagenicity: Salmonella typhimurium 2μmol/dish. Somatic mutation: 4 mg/L in mouse lymphocytes. Sperm morphology: 500 mg/kg intraperitoneally in mice (5 days). DNA damage and inhibition: human lymphocytes 250 μmol/L.

4. Teratogenicity[10] The minimum toxic dose (TDLo) of 100 mg/kg given intravenously to hamsters 8 days after pregnancy caused developmental malformations of the central nervous system, eyes, ears, and musculoskeletal system.

5. Others [11] The lowest toxic dose (TDLo) in rats is 563 mg/kg (gestational day 1 to 22), resulting in stillbirth.