Dopamine treats renal failure

The kidney is a key organ in the human body. Metabolism, detoxification, etc. all depend on the kidney. However, some people may develop renal failure due to their irregular lifestyle, and most patients with renal failure are relatively weak. Certain measures should be taken to provide timely treatment. Dopamine is a good choice. It is a specific drug for treating renal failure with excellent results. Let us now take a look at the specific content of dopamine treatment for renal failure.

1. It has β-receptor stimulating effect and dopamine receptor stimulating effect. It can enhance myocardial contractility, increase blood output, and accelerate heart rate with a slight effect. It has a mild constrictive effect on peripheral blood vessels, increasing arterial pressure, and dilates visceral blood vessels (renal, mesenteric, and coronary arteries), increasing blood flow; it increases renal blood flow and glomerular filtration rate, thereby increasing urine volume and sodium excretion. Renal failure is generally divided into three types: prerenal, renal, and postrenal. Both prerenal and renal diseases are caused by insufficient renal blood flow and glomerular filtration rate, so dopamine can improve this condition and treat renal failure. It is estimated to be ineffective for post-renal renal failure.

2. Dopamine is generally only used for acute renal failure caused by acute renal ischemia. Mainly, when used in small doses, it can dilate the renal artery, improve renal ischemia, and improve acute renal failure!

3. Source and content

This product is 4-(2-aminoethyl)-1,2-benzenediol hydrochloride. Calculated on the basis of dry product, the C8H11NO2·HCl content shall not be less than 98.0%.

Characteristics

This product is white or off-white shiny crystals or crystalline powder; odorless, slightly bitter taste; the color gradually darkens when exposed to air and light.

This product is easily soluble in water, slightly soluble in anhydrous ethanol, and very slightly soluble in chloroform or ether.

Identification

(1) Take 10 mg of this product, add 1 ml of water to dissolve it, then add 1 drop of ferric chloride test solution. The solution will turn dark green. Add 1% ammonia solution and it will turn purple-red.

(2) Take this product and add 0.5% sulfuric acid solution to make a solution containing about 30 μg per 1 ml. Determine it by UV-visible spectrophotometry (Appendix IVA of Part II of the 2010 Pharmacopoeia). The maximum absorption is at a wavelength of 280 nm.

(3) The infrared absorption spectrum of this product should be consistent with the reference spectrum (Drug Infrared Spectrum Collection).

(4) The aqueous solution of this product shows the identification reaction of chloride (Appendix III of Part II of the 2010 Pharmacopoeia)

4. Dopamine is the precursor of NA and a key neurotransmitter in the hypothalamic dopamine structural model and the pituitary gland. The concentration of dopamine in the central nervous system is affected by mental factors. There is an axon connection and interaction between GnRH and dopamine at the nerve endings, and dopamine has the effect of inhibiting the secretion of GnRH.

5. Dopamine, a neuronal substance in the midbrain, directly affects people's emotions. In theory, increasing the amount of this substance can make people feel high, but it can also be addictive. Dopamine appears in the forebrain and basal ganglia. The basal ganglia is responsible for processing the emotion of fear. However, due to dopamine, the feeling of fear is replaced. Therefore, many people's addictive behaviors are caused by dopamine.