Is glutamyl transpeptidase 68 normal?

Glutamyl transpeptidase belongs to a kind of human tissue. It is generally more abundant in the kidneys, followed by the pancreas and liver. It flows through the epithelium of the hepatobiliary duct. Under normal circumstances, a normal glutamyl transpeptidase index is required to maintain the health of the body. An increase in glutamyl transpeptidase to 65 is an abnormal manifestation and may lead to liver disease, which requires timely treatment.

Glutamyl transpeptidase

Glutamyl transpeptidase is widely distributed in human tissues, with the highest concentration in the kidney, followed by the pancreas and liver. In the embryonic period, it is most abundant in the liver. In the liver, it is mainly distributed in the hepatocyte cytoplasm and intrahepatic bile duct epithelium. The γ-GT in normal human serum mainly comes from the liver. The normal value is 3-50U/L (γ-glutamyl-p-nitroaniline method).

This enzyme is only slightly or moderately elevated in acute hepatitis, chronic active hepatitis and decompensated cirrhosis. However, in obstructive jaundice, this enzyme flows back into the blood due to excretion disorder. In primary liver cancer, the synthesis of this enzyme in the liver is hyperactive, both of which can cause a significant increase in blood transpeptidase, even to more than 10 times the normal level. γ-GT is also significantly elevated in alcoholics, which helps in the diagnosis of alcoholic liver disease.

Elevated glutamyl transpeptidase levels generally indicate liver disease. Normal values ​​are generally below 50. The glutamyl transpeptidase level was 68, which was slightly elevated. This enzyme will show mild to moderate elevation in acute hepatitis, chronic active hepatitis and decompensated cirrhosis.

Clinical significance

(1) In primary or metastatic liver cancer, GGT in the blood is significantly elevated. The reason is that the increased GGT produced by cancer cells and the inflammatory stimulation of the cancer tissue itself or its surroundings increase the permeability of the liver cell membrane, resulting in an increase in GGT in the blood.

(2) Obstructive jaundice, acute hepatitis, active chronic hepatitis, biliary tract infection, cirrhosis, etc. can all increase GGT.

(3) Other diseases such as myocardial infarction, acute pancreatitis and certain drugs can increase blood GGT levels.

Glutathione transpeptidase (y-GT), the normal value is 50 units. It may rise in acute hepatitis B, but will drop after about a month; if it remains elevated for a long time, it may turn into chronic hepatitis. Chronic hepatitis B can sometimes reach 200 units or higher and is not easy to disappear. There is currently no specific effect to reduce it. Other conditions such as alcoholic liver disease, fatty liver, cholelithiasis, intrahepatic bile duct stones, etc. can also increase the level; jaundice will also increase when it does not subside for a long time (cholestasis). It should be noted that if liver cancer occurs, the increase in y-GT can reach more than 10 times the normal value. The increase must be combined with other clinical data for comprehensive analysis.