What causes vitiligo?

Due to the influence of various reasons, the number of people suffering from vitiligo is increasing every year, and it is currently a common disease in dermatology. The cause of vitiligo is quite complicated. It is related to one's own immunity and genetics. Some children like to eat snacks, which leads to malnutrition and causes vitiligo. Let's take a look at the causes and complications of vitiligo. What diseases will it cause?

1. Autoimmunity

1. The incidence of vitiligo in patients with other autoimmune diseases is significantly higher than that in the general population.

2. A variety of autoantibodies and anti-melanocyte antibodies can be detected in the patient's serum, with a positive rate of 50-93%, which is related to the severity of the disease.

3. The incidence of vitiligo in patients with malignant melanoma is significantly higher than that in normal people. Among a group of 450 melanoma patients abroad, 29 (6.4%) had vitiligo.

4. Vitiligo patients have abnormalities in cellular immunity and humoral immunity, such as changes in T cell subsets, soluble interleukin-2 receptors and some cytokines.

5. The course of vitiligo is chronic and protracted, which conforms to the general rules of autoimmune diseases. Loading Vitiligo

6. Vitiligo not only affects the melanocytes of the skin, but also the pigment cells of the eyes, ears, etc.

7. Some patients showed positive isomorphic reaction.

8. During the progressive stage of pathological changes, monocytes aggregate at the edge of the white spots, which is consistent with a delayed hypersensitivity reaction, and the number of Langerhans cells in the epidermis at the edge of the white spots increases.

9. Treatment with corticosteroids and immunosuppressants is effective.

2. Melanocyte self-destruction During the melanin synthesis process, the intermediate products such as dopa, dopaquinone, dopachrome, 5-6-dihydroxyindole, etc. are all monophenol or polyphenol compounds. The accumulation or excessive production of phenolic substances are selectively cytotoxic to melanocytes and can damage melanocytes.

3. Neurochemical factors Chemical mediators released by nerve endings such as norepinephrine, acetylcholine or other substances may have a damaging effect on melanocytes.

4. Genetic factors Genetic factors play a certain relationship with the occurrence of this disease. According to reports from home and abroad, 3-40% of patients have a positive family history.

5. Other causes

1. Certain drugs: such as anticholine esterase drugs, photosensitivity drugs, sulfur-based drugs, thyroxine, norepinephrine, retinoic acid drugs, vitamin C, etc.; 2. Mental factors, sun exposure, trauma, surgery, friction, etc.; 3. Alcohol and seafood; 4. After various infectious diseases. [1] VI. Comprehensive Causes Vitiligo is a disease that causes depigmentation of the skin, mucous membranes, and hair due to a significant decrease or loss of melanocytes.

The main hazards of vitiligo are:

1. Affects appearance. When the disease occurs in exposed parts of the body, it will seriously affect the appearance of the human body and directly lead to psychological disorders in vitiligo patients. The resulting psychological disorders can in turn aggravate the spread and development of vitiligo.

2. It causes certain psychological pressure on the patient and forms psychological barriers, which in turn has a certain impact on the patient's life, study, work, marriage, daily communication, etc.

3. It may induce other diseases. Vitiligo patients lack melanin in their skin, which greatly reduces the skin's ability to block ultraviolet rays. Therefore, patients with vitiligo have poor defense against ultraviolet rays and are easily harmed by ultraviolet rays, leading to various diseases. In addition, it may also induce diseases such as pernicious anemia, alopecia areata, psoriasis, malignant tumors, bronchial asthma, rheumatoid arthritis and cataracts, as well as complications such as hyperthyroidism, diabetes, chronic active hepatitis and other diseases.